Project Grant R21CA310158
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded the Regents of the University of Michigan a $2.86 million Project Grant on September 10, 2025, with a completion date of August 31, 2029. This research initiative develops novel therapeutic strategies to combat colibactin, a carcinogenic metabolite produced by pathogenic enteric bacteria associated with colorectal cancer (CRC). The project delivers two primary products: (1) an...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $119,858 to the Regents of the University of Minnesota under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, for a project extending through July 31, 2030. This project grant supports fundamental research aimed at elucidating and overcoming T cell dysfunction in pancreatic ductal adenocarcinoma (PDA), a disease notoriously resistant to immunotherapy. The research program comprises three...
- Federal Grant Award Summary The National Cancer Institute awarded a $105,189 Project Grant to the Regents of the University of Minnesota under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, with completion targeted for June 30, 2027. This award funds research aimed at deciphering the structural dynamics and inhibition mechanisms of APOBEC3A (A3A) and APOBEC3B (A3B) enzymes, which play dual roles in host antiviral defense and genomic stability while contributing to...
- Federal Project Grant Award Summary The National Cancer Institute awarded $395,973 to the University of Minnesota (Regents of the University of Minnesota) under the Cancer Treatment Research program (CFDA 93.395) for a project focused on developing deazaflavin analogs as selective multidrug resistance protein 1 (MRP1) inhibitors for cancer chemosensitization. The award period runs from September 5, 2025 through August 31, 2027. The project delivers research and development services aimed at...
- Federal Project Grant Award Summary Mayo Clinic received a $161,400 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025 through July 31, 2027. The award supports research to develop and validate innovative ferroptosis-based therapeutic approaches targeting cholangiocarcinoma (CCA), a highly lethal malignancy of the liver and biliary tract with a five-year survival rate below 10%. The...
- Federal Project Grant Award Summary The National Cancer Institute awarded $394,532 through its Cancer Treatment Research program (CFDA 93.395) to the Regents of the University of Minnesota on July 15, 2025, to support research investigating LAT1 (L-type amino acid transporter 1) as a novel therapeutic target in colorectal cancer. The research will be conducted through June 30, 2027, and focuses on developing innovative treatment approaches for microsatellite stable (MSS) tumors, which...
- Federal Grant Award Summary The National Cancer Institute awarded a $403,686 Project Grant to the University of California, Irvine under the Cancer Treatment Research program (CFDA 93.395) effective March 19, 2026, with a completion date of February 28, 2027. This research initiative will develop and validate a genetic screening approach to identify synergistic drug-diet interactions that enhance cancer therapy efficacy. The principal deliverables include the establishment of an unbiased,...
- Federal Grant Award Summary The National Cancer Institute (NCI), under its Cancer Treatment Research program (CFDA 93.395), awarded Weill Medical College of Cornell University a Project Grant of $606,839 effective June 1, 2025, through May 31, 2030. This research initiative investigates the role of gut microbiota amino acid metabolism in cancer development and progression. The award funds research designed to identify specific microbes and their genes that deplete intestinal amino acids and to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $160,431 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to the University of Tennessee Health Science Center, effective December 1, 2025. This F31 fellowship grant supports predoctoral research training focused on investigating the mechanistic relationship between gut microbiome modulation and breast cancer (BC) outcomes in the context of obesity and weight loss. The research aims to identify...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Minnesota a $309,761 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective May 1, 2026, through April 30, 2031. The award funds development and delivery of an innovative training course in biomarker development and applications for cancer prevention research. The course combines virtual didactic modules on chemical carcinogenesis fundamentals with a five-week...
The University of Minnesota's Office of Sponsored Projects Administration received a $408,829 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective May 1, 2026 through April 30, 2028. This award supports research aimed at developing a novel therapeutic approach to treat cholangiocarcinoma (bile duct cancer) by restoring primary cilia in cholangiocytes through microbiota-derived butyrate supplementation. The research will investigate how dietary interventions that promote bacterial butyrate production in the gastrointestinal tract can maintain and rescue ciliary expression, thereby reducing disease progression in this aggressive cancer. Butyrate, a short-chain fatty acid produced during bacterial fermentation of dietary fiber, functions as a SIRT1 (silent information regulator 1) inhibitor and has shown preliminary promise in restoring ciliary expression and reducing tumor cell proliferation. The research addresses a critical gap in cholangiocarcinoma treatment by exploring the mechanistic relationship between gut microbiota-derived metabolites and cholangiocyte ciliary dysfunction. Deliverables from this two-year project will include laboratory findings demonstrating whether dietary fiber interventions and specific bacterial strains can enhance butyrate production, preclinical data establishing the efficacy of butyrate in rescuing ciliary expression, and validation of the SIRT1 inhibition pathway as a therapeutic target. This work is positioned to advance understanding of cholangiociliopathies and generate evidence supporting potential dietary or pharmaceutical interventions for cholangiocarcinoma treatment, contributing to the NCI's broader mission of developing improved cancer treatment methods.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.8k | 4/9/26 |