Project Grant R21CA309618
- The National Institute on Drug Abuse awarded the Board of Regents of the University of Nebraska $422,125 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to examine oral nicotine pouch use and health effects among adolescents and young adults. The recipient, through its University of Nebraska Medical Center division in Omaha, Nebraska, will harmonize nationally representative population assessment data from the PATH Study waves 7–9 (2022–2025) to investigate oral...
- The National Cancer Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $948,630 under the Cancer Cause and Prevention Research program (CFDA 93.393) on August 1, 2026, for a naturalistic cohort study examining the real-world effectiveness of smoking cessation aids in US adults. The project will conduct a longitudinal survey study using the Understanding America Study, a nationally representative panel of 20,000 US...
- The National Cancer Institute awarded the Regents of the University of Minnesota $621,549 under the Cancer Cause and Prevention Research program (CFDA 93.393) on June 1, 2026. The award funds a randomized experimental marketplace study evaluating nicotine pouches as a potential substitute for combustible menthol cigarettes in the context of menthol flavor bans. The research specifically examines the acceptability of nicotine pouches relative to medicinal nicotine among menthol cigarette smokers,...
- The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $1,639,996 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077). The award funds a clinical pharmacology study of oral nicotine pouches (ONPs)—small microfiber sachets filled with purified or synthetic nicotine and typically flavored. The research will examine nicotine exposure and subjective effects from...
- The National Institute of Dental and Craniofacial Research awarded Health Research, Inc. (Roswell Park Division) $347,000 on July 8, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a large-scale population-based study examining how the use of reduced-exposure nicotine products—electronic nicotine products and oral nicotine pouches—impacts oral health conditions among adults who formerly used combustible or smokeless tobacco in the United States. The research...
- The National Institutes of Health Office of the Director awarded The Ohio State University $773,576 on August 1, 2026, under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) to conduct research on oral nicotine pouches and their abuse liability. The research will investigate how freebase nicotine fraction and moisture content in oral nicotine pouches affect the speed of nicotine delivery to users and how acute laboratory measures of abuse...
- The National Cancer Institute awarded the University of Rochester $583,304 on August 13, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate toxicological assessment of emerging nicotine analogs in electronic nicotine delivery systems (ENDS). The research addresses a substantial knowledge gap regarding the safety profile of novel nicotine analogs, including 6-methyl nicotine and nicotinamide, which manufacturers have introduced to circumvent premarket...
- The National Institutes of Health National Cancer Institute awarded The Medical University of South Carolina $586,018 on July 10, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a three-arm clinical trial testing augmented doses of nicotine replacement therapy for individuals who use both combustible cigarettes and e-cigarettes and wish to quit both products. The trial will randomize dual-use participants to receive behavioral support combined with...
- The National Institute on Drug Abuse awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $2,107,844 on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a longitudinal mixed-methods study of nicotine pouch adoption and use patterns among U.S. adults. The research combines a nationally representative longitudinal survey with qualitative interviews to examine who uses nicotine pouches, reasons for adoption,...
- The National Cancer Institute of the National Institutes of Health awarded the University of Southern California $426,828 on July 6, 2026, through the Cancer Cause and Prevention Research program (CFDA 93.393) to test regulatory strategies promoting e-cigarette cessation among young adults. The University of Southern California will conduct a study using a simulated vape shop experimental laboratory space ("The Puff Point") to evaluate two innovative policy interventions designed to...
The National Cancer Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $179,403 on August 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to examine longitudinal effects of nicotine pouch use on tobacco use behaviors, biomarkers, and nicotine dependence among U.S. adults. The research will harmonize nationally representative population assessment data from the PATH (Population Assessment of Tobacco and Health) Study waves 7–9 (2022–2025), combining interview survey data with restricted biomarker data to characterize tobacco use transitions and health outcomes associated with adult nicotine pouch use. The study responds to evidence that nicotine pouch sales increased 641 percent between August–December 2019 and January–March 2022, and seeks to elucidate whether complete transition from combustible cigarettes to nicotine pouches could serve as a harm reduction strategy to lower cancer-related risks, given that pouches avoid respiratory exposure and lack certain tobacco toxicants present in cigarettes. Performance occurs in Omaha, Nebraska. The period of performance runs from August 1, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $179.4k | 7/27/26 |