Project Grant R21CA307898
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Colorado-Denver $584,510 under the Cancer Biology Research program (CFDA 93.396) on September 12, 2025, with completion scheduled for August 31, 2029. This Project Grant supports the continued development and implementation of advanced spatial transcriptomics and proteomics technologies within the Human Immune Monitoring Shared Resource (HIMSR), a core facility of the University of Colorado Cancer Center...
- Federal Grant Award Summary The University of Colorado-Denver received a $547,080 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on September 17, 2025, with an ultimate completion date of August 31, 2029. This award supports the University of Colorado Cancer Center's (UCCC) initiative to advance cancer screening and prevention trials through enhanced clinical trial accrual and increased diversity in participant enrollment....
- Federal Project Grant Award Summary The National Cancer Institute awarded the University of Colorado-Denver $491,315 under the Cancer Biology Research program (CFDA 93.396) on September 12, 2025, with a completion date of August 31, 2029. This Project Grant supports the Functional Genomics Shared Resource (FGSR) at the University of Colorado Cancer Center, directed by Dr. Molishree Joshi, which provides advanced functional genomics technologies and services to academic research laboratories. The...
- Cooperative Agreement Award Summary The National Cancer Institute (NCI) awarded a Cooperative Agreement valued at $625,470 to The Regents of the University of Colorado (University of Colorado-Denver) under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026 through April 30, 2031. The award supports research into novel dietary interventions targeting endocrine therapy resistance (ETR) in estrogen receptor (ER)-positive breast cancer. The project investigates how...
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), awarded a Project Grant of $770,666 to the University of Colorado's Office of Contracts and Grants (awarded March 19, 2026; completion February 28, 2028) to conduct fundamental research on splicing-mediated dysregulation of interferon signaling in cancer. The project investigates how transposon-derived exonization creates altered protein isoforms of the IFNAR2 gene that...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $156,000 through its Cancer Biology Research program (CFDA 93.396) to the University of Colorado–Denver for a two-year project (April 1, 2026–March 31, 2028) focused on optimizing pre-clinical models of adamantinomatous craniopharyngioma (ACP), a rare and highly morbid pediatric brain tumor. The project addresses critical gaps in available research tools by refining and validating patient-derived organoid (PDO) and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $246,362 to the Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) on June 12, 2026, with a completion date of May 31, 2031. This Project Grant funds research to elucidate the mechanisms by which homologous recombination deficiency (HRD), particularly BRCA2 mutations, affects estrogen receptor-positive (ER+) breast cancer responsiveness to endocrine therapy. The...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $482,236 to Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) on August 1, 2025, with a project completion date of July 31, 2030. This investigator-initiated Phase 2 clinical trial will evaluate the safety and efficacy of combining trastuzumab deruxtecan (T-DXD), an antibody-drug conjugate, with the anti-EGFR (epidermal growth factor receptor)...
- Federal Grant Award Summary The National Cancer Institute, under its Cancer Treatment Research program (CFDA 93.395), awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 effective June 1, 2026, with completion targeted for May 31, 2028. This award supports research into fragment-based targeting of epithelial-to-mesenchymal transition (EMT)-mediated resistance in epidermal growth factor receptor (EGFR)-mutant lung cancer. The project leverages...
- Grant Award Summary The National Cancer Institute (NCI) awarded $545,195 to the University of Arizona under the Cancer Biology Research program (CFDA 93.396) on July 10, 2026, for a five-year project extending through June 30, 2031. The project, "Interrogating Niche-Specific Nuclear and Extra-Nuclear Estrogen Receptor-Alpha (ER) Signaling to Prevent ER+ Breast Cancer Progression in ER+ Bone," investigates mechanisms by which estrogen receptor signaling drives estrogen receptor-positive...
Grant Award Summary The National Cancer Institute awarded University of Colorado-Denver a $417,074 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 13, 2026, with a completion date of June 30, 2028. The award funds research targeting context-specific estrogen receptor (ER) complexes to improve treatment outcomes for invasive lobular carcinomas (ILCs), the most common histopathological subtype of breast cancer. The research addresses a critical gap in current endocrine therapy: while selective estrogen receptor modulators (SERMs) and degraders/downregulators (SERDs) effectively treat invasive ductal carcinomas (IDCs), these same therapies act as weak estrogens that promote proliferation in ILC cells, contributing to worse long-term patient outcomes. The investigative work will identify ILC-specific estrogen receptor co-regulatory proteins and their mechanisms to enable development of more effective targeted therapies for this patient population. The project deliverables include fundamental laboratory research characterizing differential ER:co-regulator interactions between ILC and IDC cell types, genetic ablation studies of ILC-specific ER co-regulators to restore tamoxifen sensitivity, and comprehensive functional analyses to support future therapeutic development. Findings are expected to provide a scientific foundation for designing next-generation endocrine therapies specifically optimized for lobular breast cancer patients who currently lack access to the full pharmacologic range of ER-targeting treatments available to ductal carcinoma patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $417.1k | 7/13/26 |