Project Grant R50CA293856
- The University of Colorado Functional Genomics Shared Resource (FGSR) received a $358,574 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to purchase a Sartorius CellCelector Flex system. This advanced cell imaging and handling technology will empower cell line development, rare cell detection, and analysis capabilities for 8 major and minor investigators conducting NIH-funded research across diverse areas such as oncology,...
- This federal Project Grant award of $584,510.00, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports the development of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. The award enables the University of Colorado-Denver to implement new imaging techniques and computational approaches to enhance the capabilities of its Human Immune Monitoring Shared Resource (HIMSR). This will allow...
- The University of Colorado Cancer Center (UCCC) has been awarded a $547,080 Project Grant from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) to advance cancer screening and prevention trials. The grant aims to increase patient accrual and diversity in clinical trials, with a focus on expanding the number of National Clinical Trials Network (NCTN) trials and launching a new cancer prevention and survivorship modality team within the UCCC's Cancer Clinic Trials Office....
- This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for...
- This $375,134 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a novel approach for reducing the off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize an innate immune response that can be leveraged to limit nanoparticle deposition in healthy tissues, thereby enhancing delivery to tumors and improving the efficacy of chemotherapy. The 5-year project, starting on March 1, 2025,...
- This $150,104 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to understand the evolutionary trajectories of complex genomic rearrangements in cancer. The project aims to develop novel computational approaches, "AGAVE" and "ROSE", to characterize the timing and dynamics of focal amplifications and structural variants during tumor evolution. The research will map these evolutionary patterns across...
- This federal Project Grant award of $204,474, awarded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), is supporting research to define the transition from deep cell quiescence to senescence. The University of Colorado, the awardee, will use time-lapse microscopy and molecular assays to investigate the mechanisms controlling quiescence depth and the relationship between deep quiescence and senescence. The research aims to determine if senescence is a form of...
- This $204,027 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting the Weill Medical College of Cornell University in expanding single-cell and spatial technologies to link clonal genotypes with phenotypes during cancer evolution. The grant aims to develop advanced single-cell methods that can capture multiple data modalities, including genotypes, transcriptomes, methylomes, and protein expression, to better understand how somatic...
- This $521,579 Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports research to identify critical regulators controlling clear cell renal cell carcinoma (CCRCC) lung metastasis. The University of Texas Southwestern Medical Center, the awardee, will conduct a genome-wide CRISPR screen to characterize the role of the hepatic leukemia factor (HLF) in CCRCC lung metastasis and examine the underlying molecular...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training program) supports research at Jackson State University to investigate the role of the IGF2BP1 protein in colorectal cancer drug resistance. The $146,280 award, effective August 1, 2025 through July 31, 2029, aims to determine the in vivo efficacy of IGF2BP1 inhibition in sensitizing chemoresistant colorectal cancer cells to chemotherapeutics, as well as assess...
The National Cancer Institute (NCI) awarded a $491,315 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the University of Colorado Cancer Center (UCCC). The grant will support the work of Dr. Molishree Joshi, Associate Director of the Functional Genomics Shared Resource (FGSR) at UCCC, to further develop and expand the FGSR's capabilities in providing essential functional genomics technologies and services to academic researchers across Colorado. The FGSR, under Dr. Joshi's leadership, maintains and operates three major platforms: shRNA, ORF, and CRISPR, offering pre-made reagents and customized solutions to support groundbreaking cancer research. The grant will enable the FGSR to continue innovating and integrating new complementary technologies to drive advancements in understanding cancer biology, developing personalized therapies, and initiating clinical trials. This award builds on the FGSR's significant contributions, which have supported over 360 academic labs, facilitated more than 250 publications, and enabled 85 NCI-funded grants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $491.3k | 9/10/25 |