Project Grant R21CA307819
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Emory University a $156,500 Project Grant on August 1, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct integrated multi-omics research exploring the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The two-year project, concluding July 31, 2027, will investigate the systemic biological mechanisms underlying cancer cachexia through comprehensive analysis of...
- Federal Grant Award Summary Emory University received a $1.42M Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2025, through March 31, 2030. This R01 research grant supports a translational research initiative investigating neoadjuvant combination immunotherapy for melanoma treatment. The research team, led by Dr. Paulos (T cell immunologist) and Dr. Lesinski (translational scientist), will conduct...
- Federal Project Grant Award Summary Emory University received a $646,181 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective April 2, 2026, with a completion date of March 31, 2031. The award funds research investigating the role of clonal hematopoiesis (CH)—an age-related condition affecting over 20% of individuals aged 70 and older—in non-small cell lung cancer (NSCLC) development through immune dysregulation mechanisms....
- Federal Grant Award Summary The National Cancer Institute awarded University of California, San Diego a $699,929 Project Grant on June 20, 2025, under the Cancer Treatment Research program (CFDA 93.395) to enhance immunotherapy response in human papillomavirus negative head and neck squamous cell carcinoma (HPV-HNSCC). The project, which extends through May 31, 2030, focuses on improving dendritic cell (DC) migration to draining sentinel lymph nodes to enhance the efficacy of programmed...
- Federal Project Grant Award Summary Emory University received a $402,401 project grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026 through March 31, 2028. The award supports research to develop enhanced treatment strategies for HER2-negative and HER2-low breast cancers through investigation of ionizing radiation combined with trastuzumab deruxtecan (T-DXD), an antibody-drug conjugate. The research aims to overcome...
- Federal Project Grant Award Summary Emory University received a $158,899 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded June 20, 2025, with completion targeted for May 31, 2027. This award supports the development of an innovative Simultaneous Intensity Energy Modulation and Compensation (SIEMAC) optimization platform and integrated quality assurance (QA) system for conformal flash proton therapy treatment of central lung...
- Federal Grant Award Summary The National Cancer Institute awarded Columbia University's Health Sciences Division a $683,970 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, through March 31, 2031. This award supports research on tumor-penetrating stromal modification of pancreatic ductal adenocarcinoma (PDAC) through investigation of the αvβ5 integrin pathway. The project focuses on developing and evaluating the IRGD tumor-penetrating peptide as...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Georgia State University Research Foundation Inc. a $406,258 Project Grant on July 15, 2025, under the Cancer Treatment Research program (CFDA 93.395) to develop novel covalent anti-cancer drugs utilizing phosphorus fluoride exchange (PFEX) click chemistry. The two-year research initiative, concluding June 30, 2027, focuses on designing privileged covalent warheads with expanded target scopes to overcome limitations of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $901,205 to Boston Children's Hospital under the Cancer Treatment Research program (CFDA 93.395) effective July 3, 2025, with a completion date of June 30, 2032. This research initiative focuses on identifying genome-wide changes in gene expression during early tumorigenesis and metastatic progression to improve immunotherapy efficacy. The project leverages genetically engineered mouse models...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
The National Cancer Institute awarded Emory University a $402,401 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on April 6, 2026, with completion scheduled for March 31, 2028. This research initiative focuses on developing sex-specific immunotherapeutic approaches to overcome resistance to immune checkpoint inhibitors (ICI) in pancreatic ductal adenocarcinoma (PDAC). The project delivers integrated research services encompassing basic and translational investigation of immune checkpoint mechanisms, specifically targeting the vasoactive intestinal polypeptide receptor (VPAC) as a novel immune suppression pathway. Research products include characterization of sex-specific differences in macrophage-mediated anti-tumor immunity, functional assays assessing the impact of VPAC and androgen receptor inhibition on tumor immunity, and preclinical evaluation of combination therapeutic approaches pairing VPAC blockade with macrophage checkpoint inhibitors and programmed death-1 (PD-1) blockade. The research employs advanced analytical methodologies including multiplex fluorescence microscopy, single-cell RNA sequencing, and functional immunological assays to elucidate mechanisms of immune evasion in male and female PDAC models. Deliverables are anticipated to include scientific findings and data supporting sex-stratified therapeutic strategies designed to enhance immune-permissive tumor microenvironments and improve ICI efficacy in PDAC treatment. The investigation builds upon institutional capabilities at Emory University's Atlanta, Georgia location, leveraging the institution's established expertise in biomedical research and federal grant execution across the National Institutes of Health funding portfolio.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $402.4k | 4/6/26 |