Project Grant R61CA297882

Award Date 1/2/25
Completion Date 12/31/27
Dollars Obligated $219K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
New York, NY 10027, USA
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The National Cancer Institute (NCI) awarded Duke University a $387,702 R21 project grant (CFDA 93.396 Cancer Biology Research) to develop an automated bipartite algorithmic pipeline that leverages recent advancements in protein language modeling and co-complex databases to design peptide binders that can induce targeted protein degradation. This "ubiquibody" platform aims to enable the development of protein degraders for intractable cancer targets that are challenging to address...
This $360,100 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and biological applications of red light bioconjugation and proximity labeling platforms using Os(II) photocatalysts. The key products and services being delivered under this project include: A method for selective bioconjugation of aspartic acid (Asp) and glutamic acid (Glu) residues, where red...
This $169,932 federal Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the advancement of proteomics technologies for cancer research at the Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University. The Principal Investigator (PI), the Technical Director of the Proteomics and Macromolecular Crystallography Shared Resource (PMCSR) at HICCC, aims to enhance the center's capabilities by developing innovative methodologies,...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $849,371.00 to support research aimed at "Hijacking Post-Translational Arginylation for Targeted Protein Degradation". The project is focused on developing novel "arginylation targeting chimera" (ARGTACs) technology to leverage the cellular arginylation pathway for targeted degradation of cancer-related proteins. Key aspects of the work include: Establishing the ARGTAC...
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This federal Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) is supporting the development of tools to enable the rapid, high-sensitivity analysis of changes in protein interactions within one minute or less. The $449,726 award to the University of Illinois will fund the creation of three orthogonal methods that significantly reduce background noise during biotinylation, allowing for the detection of dynamic protein complexes in living cells. The...
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The National Cancer Institute (CFDA 93.396 Cancer Biology Research) awarded a $218,886 Project Grant to Columbia University to develop a novel technology for light-activated, targeted protein degradation in cancer cells. The three-year project aims to:

  1. Optimize a catalytic system and cleavage reactions for efficient light-catalyzed protein degradation.
  2. Demonstrate the system's ability to degrade the cancer-relevant cell surface protein PD-1.
  3. Optimize catalysts for degrading the oncogenic phosphatase SHP2.

This technology leverages photoproximity labeling to selectively induce protein cleavage and degradation in cancer cells, without relying on endogenous degradation pathways. The deep red light-activated system offers spatial and temporal control over protein elimination, enabling targeted ablation of cancer proteins for both research and potential therapeutic applications.

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