Project Grant R21CA303372
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $401,115 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025, through July 31, 2027. The award funds research to develop and validate contrast-enhanced ultrasound (CEUS) as a diagnostic tool for evaluating hepatocellular carcinoma (HCC) treatment response following transarterial...
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $646,208 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period May 1, 2026 through April 30, 2031. The award supports research to identify spatial heterogeneity of Human Epidermal Growth Factor Receptor 2 (HER2) expression in luminal estrogen receptor-positive (ER+) breast cancer and develop predictive tools for...
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $484,405 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year award supports fundamental cancer biology research investigating NSD2 (Nuclear Set Domain Family Member 2) mutations and their role in driving acute lymphoblastic leukemia (ALL) transformation. The research...
- Federal Project Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $1,656,379 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective March 6, 2026, with an ultimate completion date of February 28, 2031. The grant funds a comprehensive five-year research initiative investigating neuroendocrine prostate cancer (NEPC) progression and identifying novel therapeutic vulnerabilities....
- Federal Project Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $1.1 million project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), awarded June 1, 2026, with completion targeted for May 31, 2030. The grant funds a four-year biomedical research initiative investigating chemoradiation-imparted KRAS (Kirsten rat sarcoma viral oncogene homolog)-mediated resistance to immunotherapy in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $477,674 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective June 1, 2026 through May 31, 2031. This research project focuses on developing molecular and functional imaging methodologies to understand the immune-suppressive tumor microenvironment (TME) in prostate cancer, with particular emphasis on the roles of hypoxia, metabolism, fibroblasts, and...
- Federal Grant Award Summary Thomas Jefferson University received a $769,390 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 11, 2025, with a completion date of July 31, 2030. The research project develops and validates a novel clinical treatment approach using ultrasound-triggered microbubble destruction (UTMD) combined with local antibiotics to enhance antibiotic...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $162,080 under the Cancer Research Manpower program (CFDA 93.398) on December 27, 2025, with a completion date of June 30, 2028. Dr. Komatsu's laboratory is conducting research to visualize and characterize B cell infiltration and aggregation within the tumor microenvironment, with particular focus on the role of high endothelial venules (HEVs) as critical gateways for...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $813,921 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 19, 2026, with a completion date of January 31, 2031. The research investigates trained immunity mechanisms induced by messenger ribonucleic acid (mRNA) lipid nanoparticle (LNP) vaccines and their...
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), awarded the University of California, San Diego a Project Grant of $694,643 on May 7, 2026, with an ultimate completion date of April 30, 2031. This award supports research targeting the Hippo-YAP/TEAD signaling network in head and neck squamous cell carcinoma (HNSCC), with the objective of developing improved treatment approaches for this disease. The research addresses...
Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $401,115 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded on June 4, 2026, with a completion date of May 31, 2028. The grant funds research into microbubble-augmented neoadjuvant anti-programmed death-1 (anti-PD1) immunotherapy for head and neck squamous cell carcinoma (HNSCC), a disease with a 5-year survival rate of 55%. The research addresses the limited treatment response rates (20-30%) observed with current neoadjuvant immunotherapy approaches by investigating how contrast-enhanced ultrasound (CEUS) microbubbles can enhance tumor drug delivery and immunotherapy efficacy. The funded research will deliver two primary products: (1) a demonstration of the feasibility and preliminary efficacy of microbubble-augmented neoadjuvant anti-PD1 immunotherapy in HNSCC patients prior to surgery, and (2) development of quantitative imaging biomarkers to predict patient treatment response. The project builds upon the awardee's prior successful safety and efficacy validation of microbubble cavitation techniques in liver cancer radiotherapy and pancreatic cancer chemotherapy, translating these preclinical findings and established methodologies into a clinical application designed to improve outcomes for HNSCC patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $401.1k | 6/8/26 |