Project Grant R01CA294824

Award Date 4/1/25
Completion Date 3/31/30
Dollars Obligated $539K
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This $607,131 Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) is funding a research project to develop an MRI-guided robotic system for minimally invasive, personalized prostate cancer surgery. The overarching goal is to replace invasive radical prostatectomy with targeted, image-guided focal resection of prostate tumors. The key products/services being developed include: 1) Fast intraoperative low-field MRI imaging to...
The National Cancer Institute (NCI) awarded a $692,072 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to The University of Texas Southwestern Medical Center. The grant, effective September 19, 2024 through August 31, 2029, aims to develop a multimodal theranostic platform targeting prostate cancer (PC). The proposed theranostic agents leverage Prostate-Specific Membrane Antigen (PSMA) targeting to enable concurrent positron emission tomography/computed...
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This $538,553 project grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) will fund a longitudinal study to investigate the use of quantitative multiparametric MRI (mpMRI) features and circulating tumor cells (CTCs) as early markers of treatment outcomes for prostate cancer patients receiving radiotherapy with androgen deprivation therapy (RT+ADT).

The key objectives are to: 1) define the role of mpMRI habitat risk score features in predicting biochemical and clinical disease outcomes, 2) assess the utility of CTCs quantified using microfiltration in monitoring response to RT+ADT, and 3) develop a multivariable model that integrates mpMRI and CTC data to guide treatment decisions on intensification or de-intensification of radiotherapy. This 5-year study will be conducted by the University of Miami's Office of Research Administration - School of Medicine Division, leveraging data from several of the university's ongoing prostate cancer radiotherapy clinical trials.

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