Project Grant R21CA299783
- Federal Grant Award Summary The Ohio State University received a $384,524 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on June 17, 2026, with completion scheduled for May 31, 2028. The award supports preclinical research and development of a novel immunotherapeutic platform utilizing targeted prodrug cytokines for metastatic breast cancer treatment. The research deliverables include in vitro and in vivo investigations of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University a $621,574 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. This five-year research initiative investigates the regulatory mechanisms of AMP-activated protein kinase (AMPK) in tumor-associated macrophages (TAMs) to develop novel strategies for enhancing cancer immunotherapy efficacy. The research addresses a critical gap in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University a $449,222 Project Grant effective August 20, 2025, through July 31, 2030, under the Cancer Treatment Research program (CFDA 93.395). This award funds research to elucidate the cellular and molecular mechanisms by which PD-1H (Programmed Death-1 Homolog, also known as VISTA) mediates immune suppression in acute myeloid leukemia (AML) and to evaluate its potential as a therapeutic target. The...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University a Project Grant totaling $192,564 under the Cancer Research Manpower program (CFDA 93.398) effective September 1, 2025, through August 31, 2028. This award supports the development of chimeric antigen receptor (CAR) modified natural killer (NK) cell-based immunotherapy for the treatment of pediatric solid tumors. The research aims to advance NK cell engineering as a safer and more effective...
- Federal Grant Award Summary The Ohio State University received a $390,906 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2027. This research initiative, titled "Decoding Dural Nociceptors as Drivers of Immune Suppression in Glioblastoma," investigates the role of pain-sensing sensory neurons (nociceptors) in regulating the immunosuppressive tumor microenvironment...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Ohio State University a Project Grant of $157,500 under the Cancer Cause and Prevention Research program (CFDA 93.393) on July 15, 2025, with completion scheduled for June 30, 2027. This award supports research investigating the roles of the TIP60 chromatin remodeling complex in DNA double-strand break (DSB) repair mechanisms. The research focuses on understanding how the TIP60 complex, particularly through its KAT5...
- Federal Grant Award Summary Case Western Reserve University received a $630,108 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective March 13, 2026, with completion targeted for February 28, 2030. The award funds research into theranostic approaches for breast cancer treatment utilizing a novel compound designated AKRO-6QC, which functions as both a targeted fluorescence imaging agent for image-guided...
- Federal Grant Award Summary The Ohio State University received a $1,574,999 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) awarded on June 15, 2025, with a completion date of June 14, 2028. The project, titled "SLIT2 as a Novel Approach for Targeting Metastatic Breast Cancer," is conducted through the university's Office of Sponsored Programs in Columbus, Ohio. This award supports advanced biomedical research aimed...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Illinois a $386,279 Project Grant on July 10, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop innovative immunotherapy screening capabilities. The grant funds the creation of a microfluidic device cassette and associated functional immune assay protocols designed to enable personalized immunotherapy screening directly on core needle biopsies from cancer patients. This...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University $463,692 under the Cancer Biology Research program (CFDA 93.396) for a five-year project (June 1, 2026 – May 31, 2031) focused on comprehensive structural and dynamic characterization of human K-RAS oncoprotein. The project delivers fundamental research services aimed at understanding K-RAS interactions with binding partners and small-molecule ligands in both normal and oncogenic mutant...
The National Cancer Institute awarded The Ohio State University a Project Grant of $394,695 under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on June 17, 2026, with a completion date of May 31, 2028. This award supports development and validation of computational approaches to identify and characterize tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) in breast cancer tissue samples. The project aims to overcome limitations in current pathologist-based enumeration methods by leveraging digital pathology and artificial intelligence-based techniques, thereby standardizing assessment of the tumor immune microenvironment (TIME) across breast cancer diagnoses. The grant deliverables include benchmarking of two computational TIL enumeration approaches and RNA sequencing-based immune quantification methods against pathologist counts as the gold standard, and evaluation of these approaches' association with patient event-free survival outcomes using data from two completed Phase III breast cancer clinical trials. Additionally, the project will develop a novel computational methodology to enumerate and phenotype TAMs, addressing a significant gap in standardized assessment tools for key microenvironmental elements. These products are designed to democratize access to TIL and TAM assessment and improve prognostic capabilities for breast cancer patients, with research conducted at The Ohio State University's location in Grandview, Ohio.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $394.7k | 6/18/26 |