Project Grant R21CA309473
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University a $449,222 Project Grant effective August 20, 2025, through July 31, 2030, under the Cancer Treatment Research program (CFDA 93.395). This award funds research to elucidate the cellular and molecular mechanisms by which PD-1H (Programmed Death-1 Homolog, also known as VISTA) mediates immune suppression in acute myeloid leukemia (AML) and to evaluate its potential as a therapeutic target. The...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $10.1 million Project Grant on September 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct the MODEL-PAIN study, which will model diverse experiences and longitudinal trajectories of pain in emergency department settings. The research project, scheduled to conclude August 31, 2029, will conduct a prospective observational study of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Ohio State University $192,564 under the Cancer Research Manpower program (CFDA 93.398) beginning September 1, 2025, with completion targeted for August 31, 2028. This project grant supports the development of chimeric antigen receptor (CAR) modified natural killer (NK) cell-based immunotherapy for pediatric solid tumor treatment. The research aims to advance NK cell engineering as an alternative to CAR T cell...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Ohio State University a Project Grant of $157,500 under the Cancer Cause and Prevention Research program (CFDA 93.393) on July 15, 2025, with completion scheduled for June 30, 2027. This award supports research investigating the roles of the TIP60 chromatin remodeling complex in DNA double-strand break (DSB) repair mechanisms. The research focuses on understanding how the TIP60 complex, particularly through its KAT5...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $608,558 project grant under the Cancer Biology Research program (CFDA 93.396) to the Research Institute at Nationwide Children's Hospital, effective April 2, 2026 through March 31, 2031. This award supports fundamental research aimed at understanding the genetic and metabolic characteristics of high-risk neuroblastoma to develop novel precision and immunotherapy approaches. The research leverages genetically...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant totaling $202,599 on September 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates the role of NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells) in chronic inflammation, microglia priming, and neuropsychiatric...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $513,127 Project Grant to The University of Texas MD Anderson Cancer Center on September 9, 2025, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research into the mechanisms linking cancer pain-associated neuronal activity to malignancy progression. The award, scheduled for completion August 31, 2030, supports a multidisciplinary investigation of malignant peripheral nerve sheath tumors...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Case Western Reserve University a $510,650 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year research initiative investigates biological factors driving clinical outcomes in human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). The research leverages a robust Cleveland-based cohort of 562 OPSCC...
- Federal Grant Award Summary The National Cancer Institute awarded a $710,361 Project Grant under the Cancer Biology Research program (CFDA 93.396) to J. David Gladstone Institutes, effective August 1, 2025, through May 31, 2030. This award funds the development of a spatial profiling-based immune hub perturbation platform designed to improve immunotherapy efficacy in colorectal cancer (CRC). The research addresses a critical gap in preclinical modeling by creating experimental frameworks that...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $224,274 Project Grant on November 27, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. This award supports fundamental neuroscience research investigating the mechanisms by which pediatric traumatic brain injury (PTBI) and early life stress (ELS) impair cognitive development in...
The National Cancer Institute's Cancer Biology Research program (CFDA 93.396) awarded a Project Grant of $390,906 to The Ohio State University, with performance in Columbus, Ohio, effective April 1, 2026 through March 31, 2027. This award supports fundamental research investigating dural nociceptors—pain-sensing sensory neurons concentrated in the dural layer of the meninges—as previously unexplored drivers of immune suppression in glioblastoma. The research aims to elucidate the mechanisms by which nociceptors remotely regulate glioblastoma progression and the tumor microenvironment through neuropeptide signaling, despite their anatomical separation from brain tumors. The project builds upon preliminary data demonstrating that nociceptor ablation in glioblastoma-bearing mice extends survival, transforms the tumor microenvironment from an immunosuppressive to an immune-activating state, and enhances responsiveness to immune checkpoint blockade therapy. This one-year project will investigate how tumor-derived factors activate dural nociceptors and how their neuropeptide production, particularly calcitonin gene-related peptide (CGRP), modulates anti-tumor immunity. The research directly addresses a critical gap in cancer immunology and holds potential to identify nociceptors as novel therapeutic targets for improving immunotherapy efficacy in glioblastoma, one of the most lethal cancers characterized by profound immunosuppression.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $390.9k | 3/30/26 |