Project Grant R21CA299494
Award Date
8/1/25
Completion Date
7/31/27
Dollars Obligated
$398K
Federal Agency
National Cancer Institute
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This Project Grant award, identified as R01CA299862, is funded by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The award, totaling $606,839, supports research to investigate the role of microbiota amino acid metabolism in cancer. The key objectives of this 5-year project are to: 1) identify the microbes and their genes that actively deplete intestinal amino acids, and evaluate how they affect the tumor microenvironment and cancer progression;...
This federal Project Grant award of $221,456.00 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to develop and optimize a novel approach for enriching microbes from clinical cancer samples to enable deep metaproteomic analysis. The research team, led by the Regents of the University of Minnesota, will pursue two specific aims: 1) Optimize and evaluate the CS-BONCAT (bio-orthogonal non-canonical amino acid tagging) method in samples of known...
This Project Grant award, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), will fund a pilot study to evaluate the associations of pre- and post-chemotherapy and -radiotherapy gut microbiome profiles with breast cancer recurrence and mortality. The $175,000 award will support the use of shotgun metagenome sequencing on 110 post-treatment stool samples from the Vietnam Breast Cancer Study, as well as an investigation of the impact of...
This Project Grant award from the National Cancer Institute (NCI), under the Federal Grant Program "Cancer Biology Research" (CFDA 93.396), supports research to profile patient-specific tumor-microbiome interactions and conduct quantitative molecular analyses to elucidate microbiome-mediated modulation of immune checkpoint molecules in mismatch repair-proficient, microsatellite-stable colorectal tumors. The $400,890 award to the Cleveland Clinic Lerner College of Medicine of Case...
This federal Project Grant award of $505,613, provided by the National Cancer Institute (CFDA 93.394 Cancer Detection and Diagnosis Research), will support the development of statistical and computational approaches to harness genomic data and translate findings into precision prevention strategies for cancer. The key objectives are to: Develop deep learning-based methods to identify tumor subtypes linked to adverse outcomes and robust data integration approaches to assess associations between...
This Project Grant award, funded by the National Cancer Institute (CFDA 93.395 Cancer Treatment Research), aims to develop a first-of-its-kind intervention against colorectal cancer (CRC) associated with colibactin-producing bacteria. The $627,422 award to the Regents of the University of Michigan will support a 5-year research effort to engineer E. coli bacteria to display an anti-toxin enzyme that neutralizes the carcinogenic colibactin. The project will optimize the surface display of this...
This $626,893 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Texas MD Anderson Cancer Center will fund research to study the role of bacterial-colonized microniches within tumors and their impact on intratumoral heterogeneity. The research aims to: 1) functionally map the cellular and metabolic features of these bacterial microniches within patient tumor tissues, 2) delineate the human cell types harboring intracellular...
The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $697,763 Project Grant to The University of Texas MD Anderson Cancer Center to conduct research on deciphering the critical determinants of enteric and tumor niche colonization by microbes, particularly Fusobacterium nucleatum (Fn), in colorectal cancer. The 5-year project aims to interrogate genetic factors enriched in Fn strains found in colorectal tumors versus the oral cavity, to understand how this microbe homes...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Stanford University to investigate how the human gut microbiome can be modulated to enhance immune responses against cancer, with a focus on improving the efficacy of cancer immunotherapy treatments. The $179,988 award, which runs from January 1, 2025 to December 31, 2026, aims to identify bacterial genes and functions that can boost the body's immune response to immune...
The U.S. Department of Health and Human Services' National Institutes of Health (NIH) awarded a $1,152,096 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to Battelle Memorial Institute's Pacific Northwest National Laboratory. The purpose of this project is to develop enhanced computational tools and pipelines to vastly improve identification and characterization of viral elements impacting the human microbiome. Key focus areas include using graph assemblies...