Project Grant R21CA299160
- Federal Cooperative Agreement Summary The University of Arizona received $462,092 from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct investigative research on novel immune checkpoint targets for topical immunoprevention of non-melanoma skin cancer (NMSC). The two-year cooperative agreement, effective August 1, 2025 through July 31, 2027, will deliver research services examining the role of stress-induced immune checkpoint...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $930,500 under the Cancer Biology Research program (CFDA 93.396) to the University of Arizona, effective September 10, 2025, with a completion date of August 31, 2032. This award supports fundamental research investigating loss of chromosome Y (LOY) in cancer development and progression, with particular focus on bladder cancer as a clinically relevant model. The research aims to advance understanding of how...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Connecticut a Project Grant of $444,991 under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a randomized controlled trial testing a dissonance-based intervention to reduce intentional tanning among young adults. The research leverages cognitive dissonance theory—a proven approach previously implemented at scale for eating disorder prevention—to address melanoma risk in...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $399,852 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective May 1, 2026 through April 30, 2028. The research project investigates circulating senescent-associated secretory phenotype (SASP) proteins and their relationship to age-related health outcomes in cancer survivors. The project...
- The federal Project Grant award of $1,187,274.00 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant is supporting research conducted by the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida to characterize plant-based phenolic alkanones as next-generation sun protectants for skin cancer prevention. The research project aims to develop novel, plant-derived compounds that can serve as...
- Federal Grant Award Summary The University of Iowa received a $155,500 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded July 18, 2025, with a completion date of June 30, 2027. The grant supports research establishing an in vivo Sleeping Beauty (SB) transposon mutagenesis screen in a nevi-prone zebrafish model to identify and characterize novel genetic drivers of melanomagenesis. The research addresses a critical...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $396,377 Project Grant to the University of Texas at Austin on May 7, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct comprehensive research characterizing mutational signatures at hotspots of genetic instability in human cancer genomes. The research deliverables include computational analysis of non-B DNA structures (including G-quadruplexes, Z-DNA, hairpins, and related...
- Federal Grant Award Summary Arizona State University received a $3.13 million Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on August 22, 2025, with a completion date of July 31, 2029. This research initiative, titled "The Ecology of Barrett's Esophagus," aims to develop advanced computational and machine learning methods to improve the prediction and diagnosis of esophageal adenocarcinoma (EA) progression in...
The National Cancer Institute (NCI) awarded the University of Arizona a $399,712 Project Grant effective May 19, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct exploratory research on endogenous hypochlorous acid (HOCl)-derived chloramines in skin inflammation and photocarcinogenesis. The research investigates a novel skin chloramine compound, chloro-cis-urocanic acid (Cl-cis-UCA), formed through co-exposure to solar ultraviolet (UV) radiation and environmental chlorination stress. The project focuses on defining the cutaneous occurrence and potential role of this previously unrecognized compound in skin photodamage, photoimmunosuppression, and photocarcinogenesis—conditions relevant to nonmelanoma skin cancer (NMSC) prevention, the most common malignancy in the United States. The funded research addresses a significant public health need by exploring environmental co-exposures and mechanisms that may modulate skin stress responses to solar UV radiation. As an exploratory R21 project with a completion date of April 30, 2028, the award supports basic mechanistic studies investigating the formation and biological activity of Cl-cis-UCA, contributing to the broader Cancer Cause and Prevention Research program objective of identifying cancer risks and developing prevention strategies through investigations of molecular carcinogenesis and cancer etiology in human populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.7k | 5/19/26 |