Project Grant R21CA297838
- Federal Grant Award Summary The University of Virginia received a $5.54 million Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period September 30, 2025 through September 29, 2029. The award supports research and development of focused ultrasound interventions designed to provide noninvasive precision therapy approaches for treating primary and metastatic breast cancers. Research activities will be conducted at...
- Federal Grant Award Summary The University of Virginia received a $2.66 million Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded September 1, 2025, through August 31, 2030. The award supports a coordinated research initiative to develop ceramide-directed therapeutics for acute myeloid leukemia (AML) treatment. The program integrates three inter-related research projects and four essential core facilities to define the biological...
- Federal Grant Award Summary The University of Virginia received a $1.52 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on May 15, 2025, with completion targeted for February 28, 2030. This grant funds research development of magnetic resonance (MR) image-guided focused ultrasound (FUS) technology combined with microbubbles to deliver SHIP-1 (SH2-domain-containing inositol phosphatase) neutralizing therapies across the...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $411,583 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective August 1, 2025, through July 31, 2027. This award supports the development and validation of a computational model that characterizes the relationship between perivascular spaces and interstitial fluid flow in glioma invasion. The project...
- Federal Project Grant Award Summary The University of Virginia has been awarded $2.375 million in federal funding through the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) to develop an imaging biomarker for interface astroglial scarring in blast-exposed military personnel using ultrahigh-gradient strength Magnetic Resonance Imaging (MRI). The three-year project, initiated November 1, 2025 and concluding October 31, 2028, will be conducted in...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $401,115 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025, through July 31, 2027. The award funds research to develop and validate contrast-enhanced ultrasound (CEUS) as a diagnostic tool for evaluating hepatocellular carcinoma (HCC) treatment response following transarterial...
- Federal Grant Award Summary The University of Virginia received a $1,092,610 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026 through February 28, 2030. The award supports development and validation of an Impedance-Activated Recognition, Tracking, and Sorting (IARTS) system designed to enable near-real-time, label-free identification and isolation of phenotypically plastic...
- Federal Grant Award Summary The University of Virginia received a $713,144 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to acquire a 0.55 Tesla (0.55T) Siemens Free.Max magnetic resonance imaging (MRI) scanner for biomedical imaging research. The award, dated August 15, 2025, with an ultimate completion date of August 14, 2026, supports the purchase and installation of this low-field MRI scanner...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on March 1, 2026, with a completion date of February 28, 2031. The award supports fundamental research investigating the mechanisms of genome integrity maintenance, specifically focusing on break-induced replication (BIR) at repetitive DNA sequences and its role...
- Federal Grant Award Summary The University of Virginia received a $124,487 Project Grant from the National Science Foundation's Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049) beginning September 1, 2025, through August 31, 2028. This collaborative research project will develop advanced statistical methods and computational tools for causal learning analysis of high-dimensional imaging outcomes. The primary deliverables include functional data...
The University of Virginia received a $404,349 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective April 1, 2026 through March 31, 2028. The award supports research to quantify focused ultrasound-mediated macromolecular delivery to brain tumors, specifically addressing the challenge of delivering therapeutics across the blood-tumor barrier in brain metastases. The project implements an innovative magnetic resonance imaging (MRI) approach utilizing quantitative susceptibility mapping (QSM) combined with dynamic contrast-enhanced (DCE) MRI to provide both sensitivity and spatial resolution necessary to measure biologic delivery to tumor microenvironments following focused ultrasound and microbubble treatment. This research addresses a critical clinical need, as brain metastases from advanced cancers (breast, lung, melanoma) demonstrate significantly higher patient mortality despite current surgical and radiotherapy standards of care. The project will develop advanced imaging methodology to fill key knowledge gaps in understanding drug delivery mechanisms to brain tumors, potentially enabling more effective therapeutic strategies for patients with disseminated and inaccessible metastases who lack viable treatment options. Research will be conducted at the University of Virginia in Charlottesville, Virginia.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.3k | 4/1/26 |