Project Grant R21CA296658
- Federal Project Grant Award Summary Vanderbilt University received a $2,958,465 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded September 19, 2025, with a completion date of August 31, 2029. The award supports the development of a multimodal diagnostic tool designed to improve the detection of urothelial carcinoma in situ (CIS) during bladder cancer surveillance. The project combines two complementary technologies:...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $2.097 million Project Grant to the University of California, Los Angeles under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2029. The award supports translational development of an extracellular vesicle (EV) matrix metalloproteinase (MMP) activity assay designed to assess patient treatment responses in osteosarcoma, the most common pediatric bone...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $144,193 to The Johns Hopkins University, effective September 4, 2025, through August 31, 2030, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). This award provides salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of ongoing R01 research projects. Dr. Korangath's protected...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $452,540 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 11, 2025, with a completion date of June 30, 2027. This award supports the development of a novel T-cell imaging paradigm utilizing positron emission tomography (PET) agents targeting CD8 and CD4 markers to provide real-time monitoring of endogenous T-cell trafficking, tumor...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Columbia University $128,228 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project period from July 1, 2025 through June 30, 2027. The project focuses on developing inhalable extracellular vesicles (exosomes) engineered for lung cancer treatment, addressing a critical clinical need given that lung carcinoma remains the leading cause of global cancer incidence and mortality. The research centers on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Alabama a $631,621 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an integrated top-down proteomics and phosphoproteomics platform for analyzing patient-derived ovarian cancer spheroids. The award, effective August 13, 2025, through July 31, 2028, supports the creation of personalized intact proteome maps that characterize disease states and identify markers...
- Federal Project Grant Award Summary Vanderbilt University received a $150,104 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025, with a completion date of December 31, 2026. The award supports research focused on developing small molecule inhibitors targeting the interaction between xeroderma pigmentosum complementation group A (XPA) and replication protein A (RPA)—two critical proteins in the nucleotide excision repair...
- Federal Project Grant Award Summary New York University School of Medicine received a $714,110 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2030. The award supports translational research aimed at developing and validating predictive biomarkers for follicular lymphoma (FL), an indolent B-cell lymphoma representing the most common small B-cell lymphoma in the United...
- Federal Project Grant Summary Vanderbilt University Medical Center received a $4.17 million Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded September 10, 2025, with completion by August 31, 2029. The grant supports large-scale genomic and omics research to identify genetic risk factors and therapeutic targets for colorectal adenoma (CRA) and its recurrence following polypectomy. The project establishes...
Federal Grant Award Summary Vanderbilt University Medical Center received a $449,969 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period May 1, 2026 through April 30, 2028. The award funds research to develop novel biomarkers for diagnosing malignant pleural effusion (MPE), a condition affecting approximately 200,000 individuals annually in the United States. The project addresses a critical clinical need by developing diagnostic approaches to complement pleural fluid cytology, which currently achieves only 50% sensitivity and often necessitates more invasive procedures such as thoracoscopic pleural biopsy. The research leverages a diverse pleural fluid biorepository containing 313 samples (35% African/Black participants) with detailed tumor-specific and clinical data. The project will identify and validate extracellular microRNA (miRNA) and protein biomarkers within extracellular vesicles and non-vesicular particles from pleural fluid samples, with particular focus on cytology-negative malignant pleural effusion populations where current diagnostic tests fail or prove highly invasive. This research aims to improve early detection of lung adenocarcinoma-induced malignant pleural effusion while reducing the need for invasive diagnostic procedures, thereby accelerating diagnosis and treatment initiation for affected patients. The work contributes to the NCI's broader Cancer Detection and Diagnosis Research Program objectives of developing accurate diagnostic techniques and methods for predicting disease course in cancer patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.0k | 4/21/26 |