Project Grant R01CA297582
- This $192,888 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports a research project at the University of Virginia (UVA) to investigate the use of normal colon organoids for identifying causal genetic variants associated with colorectal cancer risk. The key objectives of the project are to: 1) test the hypothesis that colorectal cancer GWAS genes are cell type-specific, and 2) determine the role of these genes within colon epithelial...
- This $399,187 federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will support research at Virginia Commonwealth University to study the role of ATG16L1 isoforms in colorectal cancer health disparities. The key objectives are to: 1) Determine whether the ATG16L1 T300T isoform, which is more predominant in African Americans, promotes more aggressive colorectal tumor growth and metastasis compared to the A300A isoform found more in...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $415,257 to the University of Virginia to conduct research aimed at identifying epigenetic and transcriptomic drivers of racial disparities in colorectal cancer risk and site-specific tumor development. The key products and services to be delivered under this 2-year award include: Identifying site-specific DNA methylation-associated gene expression signatures across different...
- The U.S. National Cancer Institute awarded a $724,840 Project Grant to the Regents of the University of California, San Francisco under the Cancer Cause and Prevention Research (CFDA 93.393) federal grant program. The grant supports a 5-year research project to investigate how persistent poverty impacts the risk of colorectal cancer through place-based factors, health behaviors, and underlying biological mechanisms. The study will leverage data from two large, geographically diverse U.S. cohorts...
- This $2,864,671 Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the Regents of the University of Michigan is focused on developing a novel strategy to enzymatically inhibit colibactin, a procarcinogenic metabolite from enteric bacteria associated with colorectal cancer (CRC). The objectives are to: (1) create engineered microbes that can deliver the colibactin inactivation protein ClbS to safely and effectively neutralize colibactin in the gut,...
- This Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), will fund a study to evaluate the impact of social determinants of health (SDOH) on early-onset colorectal cancer (EOCRC) diagnosis, treatment delays, and survival, with a focus on underserved populations in Kentucky and Georgia. The $192,610 award will support a 2-year epidemiologic study that aims to elucidate the relationship between SDOH measures and...
- The National Cancer Institute (NCI) awarded a $637,596 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to test a video-based intervention designed to reduce defensive colorectal cancer information avoidance and increase colorectal cancer screening rates. The 5-year project will conduct a randomized controlled trial to confirm the intervention's mechanisms of increasing self-efficacy and positive affect, and evaluate its efficacy in reaching those who tend to...
- This federal Project Grant award of $505,613, provided by the National Cancer Institute (CFDA 93.394 Cancer Detection and Diagnosis Research), will support the development of statistical and computational approaches to harness genomic data and translate findings into precision prevention strategies for cancer. The key objectives are to: Develop deep learning-based methods to identify tumor subtypes linked to adverse outcomes and robust data integration approaches to assess associations between...
- This federal Project Grant award of $205,700 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) supports research at the Sloan-Kettering Institute for Cancer Research in New York aimed at understanding and overcoming rapid resistance to targeted therapies in colorectal cancer. The key objectives are to evaluate how intrinsic tumor features modulate the development of resistance to targeted therapies, and to test a novel combination approach to...
- This federal Project Grant award of $133,598 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research by The Leland Stanford Junior University (Stanford University) to utilize a biobank of patient-derived premalignant colon organoid samples to investigate new chemoprevention strategies for familial adenomatous polyposis (FAP). The project aims to better understand how signaling and metabolic pathways are altered in premalignant polyps in order to...
This $4,174,595 Project Grant awarded by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research led by Vanderbilt University Medical Center to leverage omics and electronic health records data to study the genetics of colorectal adenomas (precancerous lesions) and explore drug repurposing for colorectal cancer prevention. The key objectives are to conduct genome-wide association studies, methylome-wide association studies, transcriptome-wide association studies, and proteome-wide association studies across 25,000 colorectal adenoma cases and 140,000 controls in European Americans, as well as 6,500 cases and 47,000 controls in African Americans. This will help identify genetic risk variants, DNA methylation changes, gene expression patterns, and protein biomarkers associated with colorectal adenoma development and recurrence after polypectomy. The research aims to advance understanding of the genetic basis of colorectal adenomas and identify potential therapeutic targets for colorectal cancer prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.2m | 9/10/25 |