This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $457,683 to the Beckman Research Institute of the City of Hope to develop and evaluate novel "Bio-Beacons" - tumor-targeting bacterial vectors engineered to secrete chemokines and cytokines. The goal is to increase the density of tumor-reactive immune cells, such as CD8 T cells, CD4 T cells, dendritic cells, and natural killer cells, within solid tumors. This is intended to enhance the efficacy of immune checkpoint blockade (ICB) cancer immunotherapy. The 2-year project will conduct studies to develop and characterize these Bio-Beacons, assess their impact on intratumoral immune composition, and determine any synergistic effects when combined with ICB therapy across multiple solid tumor models. If successful, the Bio-Beacon approach could be leveraged to increase the efficacy of cell-based cancer therapies like CAR-T cells.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $457.7k | 7/2/24 |