This Project Grant award issued by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), under the Cancer Treatment Research program (CFDA 93.395), provides $593,028 in funding to the Beckman Research Institute of the City of Hope to conduct research on the role of IL-6/STAT3 signaling in CIC-DUX4 fusion sarcoma metastasis and immunosuppression. The 5-year award aims to define the critical role of IL-6/STAT3 signaling in tumor cell growth and metastasis, as well as its impact on tumor-associated macrophage recruitment and immunosuppression, with the goal of developing new rational therapies for this rare and aggressive form of pediatric and young adult sarcoma. The research project seeks to improve understanding of the mechanisms by which the CIC-DUX4 fusion oncoprotein drives disease progression and metastasis, and to explore therapeutic targeting of the IL-6/STAT3 signaling pathway as a means to enhance cancer immunotherapy for this understudied patient population.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $593.0k | 4/3/25 |