This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $576,659 to Emory University to investigate tumor and host immune signatures associated with disparities in outcomes following GD2 immunotherapy in neuroblastoma patients. The key objectives are to: Perform tumor-based single cell genomic, proteomic, and functional investigations before and after chemoimmunotherapy to determine tumor immune microenvironment markers influencing event-free survival (EFS) and overall survival (OS). Conduct immunophenotyping and functional assays to define peripheral host immune markers influencing EFS and OS. Explore associations between tumor/host immune landscapes and parent-reported race, adverse social determinants of health, child genetic ancestry, and clinical outcomes. The grant includes sub-awards to Dana-Farber Cancer Institute ($107,231) and University of Florida ($100,216) to support specific research activities. The project period runs from Jul 2, 2024 to Jun 30, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $576.7k | 7/2/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
A1107231S | Dana-Farber Cancer Institute, Inc. | Project Grant R01CA285566 | $23.5k | 1/17/25 | |
A1100216S | University Of Florida | Project Grant R01CA285566 | $9.6k | 1/13/25 |