This Project Grant award of $215,985 from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) supports research to elucidate the immunological mechanisms underlying a novel liposomal-TLR agonist immunotherapy (LTAC) for ocular surface squamous neoplasia (OSSN). The research aims to investigate local immune responses to LTAC in an equine OSSN model through tumor biopsy and corneal swab analysis, as well as determine if LTAC induces systemic immunity to OSSN using antigen-specific T cell and antibody assays. This research is expected to advance the field of ocular immunotherapy and provide insights into local and systemic OSSN immunity. The award period is from April 10, 2025 to March 31, 2027, and the research will be conducted by Colorado State University.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $216.0k | 4/7/25 |