This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $635,946.00 to support fundamental research on the role of melanocyte PD-L1 expression in the immunological response to UV-induced melanoma. The research team at Dartmouth-Hitchcock Clinic will utilize autochthonous mouse melanoma models to investigate how UV-induced interferon-I signaling and inflammatory memory mediated by melanocyte PD-L1 impact tumor progression and treatment responses. The project will also validate the relevance of these mechanisms in human melanoma samples. This 5-year award, effective from July 2024 to June 2029, aims to advance the understanding of how UV exposure and related immune responses influence melanoma development and response to immunotherapies.
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