Project Grant R21CA288604
Award Date
4/1/25
Completion Date
3/31/27
Dollars Obligated
$220K
Federal Agency
National Cancer Institute
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Kentucky, USA
Similar Awards
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides funding for research to understand the role of mitochondrial RNA methylation in acute myeloid leukemia (AML), particularly in high-risk subtypes with MLL rearrangements or FLT3-ITD mutations. The $487,542 award to the Beckman Research Institute of the City of Hope aims to determine the functional importance of the mitochondrial methyltransferase METTL17 in AML pathogenesis, elucidate...
The National Institutes of Health's National Cancer Institute awarded $331,085.91 under the Cancer Research Manpower federal grant program (CFDA 93.398) to Brigham & Women's Hospital Inc. on February 1, 2021 for completion by September 30, 2022. The project grant funding will support research investigating the role of cellular senescence in chemotherapy-related cognitive impairment and the contribution of microglia to chemotherapy-induced senescence in the brain. Specifically, the grantee...
This $437,432 federal Project Grant award under the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) aims to develop strategies for eradicating leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) patients who have received initial treatment with venetoclax and azacitidine. The key objectives are to: 1) characterize and target venetoclax/azacitidine-resistant LICs, which the award recipient has found to have a distinct reliance on mitochondrial calcium...
The National Cancer Institute (NCI) awarded a $1,373,308 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the University of Pittsburgh to conduct research on metabolic mechanisms contributing to chemoresistance in high-grade serous ovarian carcinoma (HGSOC). The research aims to quantitatively map the role of acetylcarnitine-dependent histone acetylation in promoting homologous recombination-mediated DNA repair, and to investigate whether suppressing intracellular acetylcarnitine...
This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Treatment Research Program (CFDA 93.395), provides $198,103 to New York University School of Medicine to conduct research on understanding and addressing melanoma bone metastasis. The research aims to define the mechanisms by which melanoma cells colonize the skeletal microenvironment and modify the immune response, with a focus on the role of bone metastasis-associated neutrophils. Through preclinical...
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has awarded a $502,516 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to Case Western Reserve University's Office of Research Administration. This 5-year grant, starting on April 1, 2025, aims to further investigate the impacts of newly developed small molecule degraders that target the nuclear-specific Heat Shock Transcription Factor 1 (HSF1) on leukemic stem cell self-renewal in...
This Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) provides $375,134 to the University of Colorado-Denver to investigate a novel approach to reduce the off-target accumulation of chemotherapeutic nanomedicines in healthy tissues. The key objectives are to characterize the tightening response of epithelial tissues triggered by the cytokine IFN-λ, and leverage this effect to improve drug delivery to tumors while minimizing...
This federal Project Grant award for $700,288 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) aims to elucidate the molecular mechanisms underlying chemotherapy-induced neurotoxicity, with a focus on oxidative distress caused by the anti-folate drug methotrexate (MTX) in pediatric cancer patients.
The research team at Boston Children's Hospital will investigate how MTX treatment impacts the cerebrospinal fluid (CSF) and choroid plexus, which...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports the development of innovative approaches to detect and mitigate chemotherapy-induced cardiotoxicity. Specifically, the USD 402,403 grant to Emory University aims to (1) establish high-throughput functional assessment of human cardiospheres for the detection of chemotherapy-induced cardiotoxicity, and (2) evaluate novel antiarrhythmic therapies to address this side effect. The...
The National Cancer Institute (NCI) awarded a $458,698 Project Grant under the Cancer Biology Research (CFDA 93.396) program to the Regents of the University of Michigan. The grant, titled "Genes Regulating Stem and Progenitor Cell Expansion and Relapse in Acute Myeloid Leukemia", aims to study novel genes that influence normal and leukemic stem/progenitor cell expansion, and their contributions to therapy resistance and relapse in acute myeloid leukemia (AML). The 5-year project...