Project Grant R21CA280170
- The Project Grant titled "Engineered Microbes to Mitigate Intestinal Radiation Damage" was awarded by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The $160,125 award to Baylor College of Medicine aims to explore the use of the microbiome to deliver growth factors that promote survival and proliferation of radioresistant intestinal stem cells. The objective is to assess a genetically...
- This Project Grant award, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), will fund a pilot study to evaluate the associations of pre- and post-chemotherapy and -radiotherapy gut microbiome profiles with breast cancer recurrence and mortality. The $175,000 award will support the use of shotgun metagenome sequencing on 110 post-treatment stool samples from the Vietnam Breast Cancer Study, as well as an investigation of the impact of...
- This federal Project Grant award of $606,839.00, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research to identify gut microbiota that actively deplete intestinal amino acids and evaluate how they affect the tumor microenvironment and cancer progression. The primary awardee is Weill Medical College of Cornell University, a leading academic medical institution with expertise in biomedical research and translational science. The project aims to...
- This $627,422 Project Grant award from the National Cancer Institute under the Cancer Treatment Research (CFDA 93.395) program supports research by the Regents of the University of Michigan to engineer commensal bacteria that can neutralize the colibactin genotoxin produced by certain gut bacteria associated with increased colorectal cancer risk. The key products and services to be delivered under this 5-year grant include: 1) Further optimization of the surface display of the anti-toxin...
- The National Cancer Institute (NCI) awarded a $425,573 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the Magee-Womens Research Institute and Foundation in Pennsylvania. The grant supports a multi-year research effort to identify biomarkers and molecular targets for breast cancer prevention, with a specific focus on understanding the relationship between the gut microbiome, metabolites, and high mammographic breast density (MBD). The research aims to provide...
- The Defense Health Agency awarded a $1,523,243 Project Grant under the Military Medical Research and Development program (CFDA 12.420) to the Medstar Health Research Institute Inc. to evaluate the use of intravesical gentamicin coupled with the probiotic Lactobacillus rhamnosus for improving urinary health. The project will involve pre-clinical studies at Loyola University of Chicago and the University of Pittsburgh to determine the optimal administration protocols, as well as a pilot clinical...
- This federal Project Grant award, valued at $682,272.00, was provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program. The award will fund a research project entitled "Assessing Feasibility and Acceptability of a Multifaceted EHR-Integrated Mobile Health Intervention Following Radical Cystectomy" at the University of Michigan. The goal of the project is to develop and evaluate a novel, technology-enabled intervention to reduce...
- The National Cancer Institute (NCI) awarded a $386,866 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to the Regents of the University of Michigan to develop individualized estimates of treatment benefit from hormone therapy for men with prostate cancer. The project aims to integrate models for other-cause mortality risk, distant metastases, and prostate cancer-specific mortality to provide personalized estimates of treatment outcomes, and to develop a web...
- This Project Grant award, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports a study on the use of intravesical gentamicin coupled with Lactobacillus rhamnosus for urinary health. The total funding amount is $126,166.00, with the award date of September 1, 2024 and an ultimate completion date of August 31, 2027. The prime awardee is Medstar Health Research Institute Inc., a non-profit organization that has extensive...
- The University of Miami was awarded a $538,553 federal Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to conduct longitudinal research on the use of quantitative multiparametric MRI (mpMRI) features and circulating tumor cells (CTCs) as early markers of treatment outcomes for prostate cancer patients receiving radiotherapy and androgen deprivation therapy (ADT). The goal of the 5-year research project is to define the role of mpMRI and...
This $414,781 Project Grant awarded by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will support research to investigate the effects of pelvic radiotherapy on the urinary microbiome and its potential as a biomarker for radiation cystitis in prostate cancer patients. The primary awardee, the University of Rochester, will use banked urine samples from a clinical study, as well as a preclinical mouse model, to test hypotheses that: 1) radiotherapy alters the microbial composition and/or metabolic potential of the urinary tract, and 2) urinary microbiome dysbiosis correlates with patient-reported bladder dysfunction following radiotherapy. The sub-award to the Medical College of Wisconsin will contribute expertise in the mouse model experiments to evaluate if changes in the microbiome serve as a potential biomarker of radiation-induced bladder injury. This research aims to elucidate the role of the urinary microbiome in the development of a common and debilitating side effect of prostate cancer radiotherapy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.8k | 7/31/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
SUB00001011S | The Medical College Of Wisconsin, Inc. | Project Grant R21CA280170 | $48.2k | 12/11/24 |