Project Grant R21AT013586
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of Maryland, Baltimore $4.929 million on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a multi-omic, psychosocial, and environmental model of individual differences in pain and placebo responses. The project investigates chronic pain conditions, particularly...
- The National Center for Complementary and Integrative Health (NCCIH), a component of the Department of Health and Human Services National Institutes of Health, awarded $407,856 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on August 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The recipient will conduct research examining how alpha-frequency transcranial alternating current stimulation (tACS) targeting...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $597,375 on August 17, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a multi-site feasibility trial of an embedded mindfulness-based intervention delivered during radiation therapy for prostate cancer. The study, titled SUPPORT-PC (Supporting Utilization and...
- The National Institute of Mental Health awarded the University of Pittsburgh $728,751 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural mechanisms by which antidepressant placebo effects modulate mood in patients with major depressive disorder. The research dissects expectancy-driven dynamics between the salience network and default mode network using theta burst stimulation in a 200-patient, randomized, factorial design. The study...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Michigan a $6.827 million cooperative agreement on September 19, 2025, to conduct a Sequential Multiple Assignment Randomized Trial (SMART) evaluating personalized treatment algorithms for chronic low back pain across pharmacological, physical therapy, cognitive-behavioral, and mobile health self-management interventions. The University of Michigan's Back Pain Consortium Mechanistic Research...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $1.857 million on September 23, 2025, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). Northwestern University's research team will investigate the neural circuitry underlying motion-induced nausea through three specific aims: establishing the necessity and sufficiency of...
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $10.115 million on September 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a prospective observational study modeling diverse experiences and longitudinal trajectories of acute pain in emergency department settings. The study—titled MODEL-PAIN (MOdeling Diverse Experiences and Longitudinal trajectories of pain)—will enroll 2,400 emergency department patients and...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- Midwestern University received a $1.76M Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning August 1, 2025, and extending through July 31, 2029. The award supports research to develop microRNA (miRNA) as a novel therapeutic target for pain management in sickle cell disease (SCD). The project focuses on investigating let-7 family microRNA as a potential intervention to alleviate chronic pain in...
- The National Institute on Drug Abuse awarded the Regents of the University of California, San Francisco $219,526 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) for a Project Grant (R21DA065898) focused on multimodal phenotyping to predict non-response and opioid risk in chronic low back pain. The research will develop predictive tools and phenotypic subgrouping models to support precision pain management in chronic low back pain, a major driver of...
The National Institutes of Health Office of the Director awarded Northwestern University $201,725 on August 5, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213, also known as NCCIH funding) to conduct a randomized, partially blinded proof-of-concept trial identifying brain mechanisms of placebo pill responses in chronic back pain patients. The research concentrates on chronic back pain patients with inadequate pain control who may benefit from enhanced placebo responses through reinforced cues and consumption routines. The trial will recruit 40 chronic back pain patients (50 percent female, 50 percent Black) and randomize them to compare reinforced placebo pill use (using two pill colors, up to four pills per use, with positive reinforcement text messaging) against a control group. The study tests the hypothesis that enhanced placebo responses are mediated through mesolimbic opioid-dependent circuitry and uses naloxone (an opioid receptor antagonist) to identify causal mechanisms. The research will also evaluate whether enhanced placebo responses diminish experimental pain and improve motor abilities, examining expectation-based training effects on subjective perception and objective physical performance. Work is performed in Chicago, Illinois. The period of performance runs from the award date through July 31, 2028. Northwestern University's Sponsored Research Division is the recipient organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $201.7k | 8/7/26 |