This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $369,174 to Louisiana State University (LSU) to study the pathways of polyunsaturated fatty acid (PUFA) autoxidation and the cellular consequences. Specifically, the research aims to identify lipid electrophiles (LEs) formed through PUFA autoxidation, determine their PUFA and cellular pathway sources, and elucidate the...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to Beth Israel Deaconess Medical Center, Inc. (BIDMC) provides $749,474 to conduct research aimed at understanding the underlying mechanisms of failed inflammation resolution in chemical-induced cancers. The research will focus on profiling lipid autacoid mediators, including eicosanoids and specialized pro-resolving mediators (SPMs), as well as cytokines, to evaluate their role in regulating...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
The National Cancer Institute (NCI) awarded a $2,489,032 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research. The 5-year award, effective August 1, 2025, will support three highly integrated research projects focused on determining the roles, regulation, and underlying mechanisms of lipid metabolism in ferroptosis, a form of iron-dependent cell death, and exploring novel cancer therapeutic approaches based on these...
This Project Grant award of $1,262,764, provided by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, supports research by the Sloan-Kettering Institute for Cancer Research on using the flavonoid isoquercetin to inhibit protein disulfide isomerase (PDI) as an antithrombotic therapy for cancer patients. The key objectives are to: 1) determine the optimal isoquercetin dosing regimen...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund research to investigate the effect of UGT2B17 deletion and curcumin inhibition on the pharmacokinetics of the anti-inflammatory drug diclofenac. The $120,584 award to Washington State University will support a multi-year study to explore the underlying reasons for the idiosyncratic...
This Project Grant award of $147,486 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) supports research at the University of Pittsburgh to investigate the role of altered lipid metabolism in CD8 T cell exhaustion within the tumor microenvironment. The project aims to (1) evaluate the impact of abolishing citrate transport on carbon utilization and effector function of CD8 T cells in the tumor environment, and (2) determine the role of stored lipids in CD8 T cell...
This Project Grant award of $793,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Tennessee at Chattanooga (UTC) to investigate changes in bacterial cell membrane dynamics due to polyunsaturated fatty acid (PUFA) modifications. The key objectives are to: 1) Interrogate the nature and degree of PUFA incorporation into membrane phospholipids of Vibrio cholerae, and 2)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,188,750 in funding to Vanderbilt University to conduct research on fatty acid oxygenases and their lipid mediator products. The research program focuses on technically challenging questions related to lipoxygenases, their associated enzymes and proteins, and the mechanisms of biosynthesis and fate of oxidation products....
This $222,852 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to computationally assess the impact of aging-related oxidative stress on the human proteome using a novel deep learning methodology. The project will construct a deep learning-based atomic protein structure embedding method to predict the likelihood of oxidation-related modifications occurring across the entire human proteome. The...