This federal Project Grant award, provided by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund research to elucidate how terpenes, naturally occurring compounds in cannabis, can modulate pain hypersensitivity via the endocannabinoid system. The $131,453 award to the University of California, Los Angeles (UCLA) will support in vivo studies using a chronic pain mouse model...
This $675,107 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders supports research by Northeastern University to develop novel non-opioid, non-addictive analgesics for treating neuropathic pain. The key objectives are to: 1) design and synthesize new cannabinoid CB1 receptor allosteric agonist-positive allosteric modulator (CB1R AGO-PAM) and CB2 receptor...
This $433,710 federal Project Grant award was provided by the National Institutes of Health's National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award aims to fund complementary and integrative research on the unique and overlapping mechanisms of action of cannabis and kratom constituents, as well as their potential synergistic effects, in mouse models of neuropathic pain,...
This $600,000 three-year Project Grant from the US Department of Agriculture's National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) will fund research at Virginia Polytechnic Institute and State University to increase understanding of cannabinoid biosynthesis regulation in industrial hemp. Over the period of performance from May 1, 2023 to April 30, 2026, the university will map gene expression factors controlling the cannabinoid...
This Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $842,400 to Oregon Health & Science University (OHSU) to develop chemical biology tools for illuminating cannabinoid signaling pathways in opioid use disorder. The objective is to expand OHSU's cannabinoid chemical biology toolkit, particularly towards the atypical cannabinoid receptor GPR55, and apply these tools in ex vivo and in vivo...
The National Institute on Drug Abuse (NIDA) awarded a $137,619 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Washington. The grant, awarded on January 19, 2025, will support research to investigate the role of tetrahydrocannabinol (THC) in mediating pain signaling in the basolateral amygdala (BLA) brain region. The study aims to determine how THC, acting through cannabinoid 1 receptors (CB1R), alters glutamatergic neuronal activity in the BLA...
This $499,742 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program, with an award date of April 15, 2025 and an ultimate completion date of March 31, 2027, aims to develop a novel AI framework for designing new non-addictive pain relief medications to address the opioid crisis. The primary objectives are to create a generative AI system that integrates scientific knowledge and grammar-based molecular encodings to...
The National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health (NIH), awarded a $270,857 Project Grant (CFDA 93.213 - Research and Training in Complementary and Integrative Health) to Portland State University to establish a community-based research agenda for improving chronic pain self-management among young Black adults. The 5-year award, starting September 1, 2024, will support Dr. De'Sha Wolf, an early career social scientist, in conducting...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $350,000 to Creighton University to investigate the effects of environmental enrichment on the abuse liability of minor cannabinoids such as delta-8-THC and CBD. The research aims to determine if adolescent exposure to high- or low-novelty environments can alter sensitivity to these cannabis compounds using animal models....
This Project Grant award from the National Institute of Justice (CFDA 16.560) in the amount of $251,505 provided funding to Western Illinois University to develop advanced analytical methods for the quantification and stability analysis of psychotropic cannabinoids derived from hemp. The key products to be delivered under this two-year project include: Optimized LC-DAD-ESI/MS/MS methods capable of baseline separation and quantification of up to 20 cannabinoid compounds, including isomers,...