This $433,710 federal Project Grant award was provided by the National Institutes of Health's National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award aims to fund complementary and integrative research on the unique and overlapping mechanisms of action of cannabis and kratom constituents, as well as their potential synergistic effects, in mouse models of neuropathic pain, inflammatory pain, anxiety, and body temperature. The principal investigator is Temple University, which will conduct in vivo, ex vivo, and in vitro experiments to systematically determine receptor, signaling, and gene expression interactions underlying the effects of cannabidiol (CBD), cannabigerol (CBG), and mitragynine. The research seeks to elucidate if and how these constituents may work synergistically, either to potentiate therapeutic effects or exacerbate adverse effects, which could inform the development of new treatment approaches for chronic pain and anxiety. The award commenced on Aug 7, 2023 and is scheduled for completion on Jul 31, 2025.