Project Grant R21AR085974
- This Project Grant award of $691,089.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports research to investigate the role of mechanosensing and mechanotransduction in joint homeostasis and osteoarthritis (OA) susceptibility. The research aims to determine how mutations in the PIEZO1 mechanosensitive cation channel affect PIEZO1 activity and influence OA development. The project will use biophysical analyses, cellular/molecular studies, and mouse...
- This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel...
- The University of Rochester was awarded a $464,315 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year project, beginning on July 1, 2025, is to investigate the role of the L-type Ca2+ channel Cav1.2 in the development of Achilles tendinopathy. The research aims to identify early mediators in tendons in response to...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of muscle-subtendon units and their role in Achilles tendinopathy. The $666,825 award to the University of Delaware will fund a 5-year research study using advanced in vivo techniques such as MRI, ultrasound, and biomechanical assessments. The key objectives are...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to understand and address growth plate dysfunction in pediatric skeletal disorders. The $378,250 award to The Children's Hospital of Philadelphia Research Institute will fund a 6-year project to assess growth plate dysfunction, delineate the underlying cellular mechanisms,...
- This $499,229 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the mechanisms underlying adult tendon regeneration in the zebrafish model. The research aims to examine the relationship between TGFβ signaling and muscle activity in tendon regeneration, including investigating how reduced TGFβ signaling and muscle...
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to refine a computational surgical decision tool for vertebral body tethering (VBT) to treat spinal deformities in children. The $616,238 award, running from September 2025 through June 2030, will incorporate findings from a large animal model to determine how skeletal maturity and...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $686,880 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Marquette University. The grant, titled "Advancing Functional Assessment of Pediatric Flatfoot Using Weightbearing CT", will fund a 5-year research project to comprehensively study the 3D structure and function of pediatric planus (flatfoot) deformities using emerging...
- This $546,159 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Federal Grant Program (CFDA 93.846) will support a cross-sectional observational study on the relationship between foot biomechanics, metatarsal structure, and running footwear in athletes with bone stress injuries. The study will evaluate associations between foot biomechanics, intrinsic foot muscle size and...
- The federal Project Grant award of $504,442.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize molecular endotypes in pediatric scleroderma. The project aims to integrate single-cell and spatial transcriptomics with histological analysis to identify disease subgroups and inform personalized treatment strategies. By leveraging...
This federal Project Grant award in the amount of $400,693 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is focused on investigating the role of piezo-mediated mechanosensory signaling in pediatric clubfoot deformity. The key objective is to define how excessive piezo2 signaling activates aberrant TAZ signaling, causing post-tenotomy recurrence in pediatric clubfoot patients. The research aims to map the neuro-tendon interactions in human pediatric clubfoot patients who developed post-tenotomy recurrence, and test FDA-approved therapies and dietary modifications that can inhibit piezo and TAZ signaling to mitigate recurrence and enhance extremity function. This award will support this 2-year research project at The University of Texas Southwestern Medical Center to advance the understanding and potential treatment of this common musculoskeletal birth defect.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.7k | 8/26/25 |