Project Grant R21AI202648
- The National Institute of Allergy and Infectious Diseases awarded the University of Miami $617,438 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a rapid cell-based diagnostic test for urinary tract infections and antimicrobial resistance screening. The project addresses the clinical need for point-of-care UTI diagnosis and antibiotic selection. Current diagnostic methods—urine analysis and culture—require 1–3 days for results and lack...
- The National Institute of Allergy and Infectious Diseases awarded the University of Texas at Dallas $458,364 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize the role of basophils in urinary tract infection immunity. The research investigates how basophils, the rarest immune cells comprising less than one percent of circulating white blood cells, function in bladder immunity during uropathogenic Escherichia coli (UPEC) infection....
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $3.252 million on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to generate pre-IND validation data for novel bacterial metabolism inhibitors targeting antimicrobial-resistant uropathogens that cause urinary tract infections. The project addresses escalating antimicrobial resistance in uropathogenic Escherichia coli, the leading cause of UTIs...
- The National Institute of Allergy and Infectious Diseases awarded the University of South Alabama $234,000 on May 7, 2026, for Project Grant R21AI194156 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the role of amyloid-beta peptides in driving inflammation during urinary tract infections. The project investigates an emerging hypothesis that bacterial infection triggers accumulation of amyloid-beta in the kidney, leading to deleterious...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded the Regents of the University of Michigan $195,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI201758). The recipient will develop a urea-inducible library of 217 transcription factors in Proteus mirabilis, a bacterium responsible for up to 44 percent of long-term catheter-associated urinary tract...
- The National Institute of Allergy and Infectious Diseases awarded Pulmonescence Diagnostics Inc. $312,276 on July 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a urine-based rapid diagnostic test for pediatric tuberculosis. Pulmonescence is developing an optimized reagent formulation for a urine-based pediatric TB test adapted from its existing sputum-based diagnostic (RefTB). The work includes examining non-TB urine samples for interference with...
- The National Institute of Allergy and Infectious Diseases awarded Catholic University of America $596,250 on May 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to prototype a rapid antibiotic susceptibility testing platform using multiplex static gradients. The project aims to develop a microfluidic device that identifies effective antibiotics within 30 minutes for acute bacterial infections such as sepsis, urinary tract infections, and bloodstream...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $687,817 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate bacterial cell envelope signal transduction mechanisms relevant to antibiotic resistance. The recipient will conduct research to elucidate how the regulator of capsule synthesis (RCS) stress response...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $826,690 on August 20, 2026, for a Project Grant (R01AI198596) to advance antimicrobial resistance prediction through artificial intelligence and whole-genome sequencing. The recipient will develop rapid, comprehensive, and accurate antimicrobial resistance (AR) prediction methods by integrating Oxford Nanopore long-read sequencing and artificial intelligence. Work spans three...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $8.74 million on September 10, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish and operate a consortium supporting rigorous evaluation and development of early-stage tuberculosis diagnostics, including drug susceptibility tests. The award funds a fast-paced pipeline combining technology scouting, development mentoring, and clinical testing of TB...
The National Institute of Allergy and Infectious Diseases awarded the University of Texas at Dallas $465,664 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for development and validation of USENSE, an electrochemical point-of-care diagnostic platform for urinary tract infections. USENSE is a portable biosensor designed to quantitate three urinary analytes within 5–10 minutes and apply machine learning diagnostic algorithms to output UTI risk scores. The system addresses diagnostic gaps in current practice: community-acquired UTIs affect millions globally, with high recurrence rates particularly in women; confirmation requires both pathogen detection and documented symptoms to distinguish UTI from asymptomatic bacteriuria and overlapping urological conditions. The 2–3 day diagnostic window of gold-standard urine culture drives empiric broad-spectrum antibiotic prescription before confirmed diagnosis, contributing to rising antimicrobial resistance among uropathogenic bacteria. USENSE aims to enable rapid, accurate simultaneous quantitation of multiple inflammatory and microbial markers at the point of care—a capability currently unavailable—thereby reducing unnecessary antibiotic prescriptions and improving diagnostic precision. The award funds research and development conducted at the University of Texas at Dallas in Richardson, Texas, with a period of performance from September 1, 2026, through August 31, 2028. This is a project grant under the NIH assistance type for biomedical research and research training in infectious diseases and related areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $465.7k | 8/26/26 |