Project Grant R21AI202149
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $201,875 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate a novel family of alpha-helical peptides that regulate nitrogen metabolism and virulence in pathogenic Enterobacteria, particularly enteroaggregative E. coli (EAEC). The research employs human intestinal organoids alongside infection and fitness mouse models to elucidate the regulatory...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $795,313 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on subcellular definition of accumulation in Escherichia coli as a strategy to address antimicrobial resistance. The research seeks to formulate foundational principles governing molecular characteristics that define cellular penetration in bacteria, similar to Lipinski's Rule of Five...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $242,250 on April 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate microbial drivers of oral vaccine failure in undernourished populations. The research addresses environmental enteric dysfunction, a subclinical intestinal malabsorption syndrome linked to growth stunting and undernutrition. Oral rotavirus vaccination shows significantly reduced efficacy in...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $773,388 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode the cellular networks governing respiratory mucosal IgA immunity. The research addresses mechanisms driving robust respiratory mucosal immunity, particularly IgA responses following infection or vaccination, with the goal of informing next-generation mucosal vaccine strategies against...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $668,128 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop artificial intelligence and machine learning methods for hospital-acquired infection risk prediction, surveillance, and infection control. The recipient will design a multi-disciplinary approach combining deep learning, agent-based modeling, human factors, and systems science to address gaps...
- The National Institute of Allergy and Infectious Diseases awarded the University of North Carolina at Chapel Hill $233,250 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate host-microbe interactions that drive pro-fibrotic macrophage phenotypes in inflammatory bowel disease. The research focuses on defining how adherent-invasive Escherichia coli (AIEC) and other intracellular bacteria manipulate human macrophage signaling and phenotype. The...
- The National Institute of Allergy and Infectious Diseases awarded $886,942 to Benaroya Research Institute At Virginia Mason on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of commensal-specific CD8+ T cell differentiation, restraint, and dysregulation in intestinal inflammation. The award supports research into how CD8+ intraepithelial lymphocytes respond to gut microbiota under homeostasis and become dysregulated in...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $236,538 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize biofilm formation mechanisms in Shigella flexneri, the causative agent of bacillary dysentery. The research will identify structural determinants supporting ICSA-mediated bile-salt-dependent biofilm formation and evaluate the role of the ICSA bacterial adaptor protein in both...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $684,405 on July 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop mucosal immunotherapies targeting recurrent urinary tract infections and inflammatory bowel disease. The funded research advances immunomodulation via self-assembled peptides (ISAP), a platform using modular supramolecular polypeptide nanomaterials designed to elicit neutralizing antibody responses against...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $713,396 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of protective lung resident memory T cells. The project examines how lung tissue-resident memory CD8+ T cells provide broad-spectrum protection against influenza infection, including heterologous protection against variant strains. The research focuses on a...
The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of Virginia $253,445 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanistic insights into enteropathogen-mediated MUC3/4 signaling disruption and intestinal inflammation onset. The research uses human intestinal organoids to examine novel mechanisms triggering intestinal inflammation and mucosal barrier dysfunction during infection with epidemiologically and clinically relevant enteropathogens, specifically enteroaggregative Escherichia coli (EAEC) and adherent-invasive E. coli (AIEC). Both pathogens are associated with clinical and subclinical inflammatory disease; EAEC disrupts epithelial barriers and impairs tight junctions in intestinal cells, while AIEC is linked to inflammatory bowel disease pathogenesis and persistent chronic inflammation with intestinal fibrosis. The research team hypothesizes that proteases from the class-2 serine protease autotransporter of Enterobacteriaceae (C2S) family contribute to inflammatory processes and mucosal barrier dysfunction by degrading transmembrane proteins MUC3A and MUC4, which are linked to receptor tyrosine kinase signaling involved in inflammation and cancer development. The award runs through July 31, 2028, with place of performance in Charlottesville, Virginia. This is a Project Grant assistance type supporting research training and biomedical investigation in infectious diseases and related areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $253.4k | 8/12/26 |