Project Grant R21AI201981
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $703,040 on August 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop innovative treatment regimens for Mycobacterium avium complex pulmonary disease. The research addresses a critical gap in MAC lung disease treatment, where current therapies achieve only a 31 percent three-year microbiological cure rate and only one FDA-approved drug exists. The project...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $155,227 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 9, 2025, with completion scheduled for May 31, 2027. The grant supports proof-of-concept research on an unconventional treatment regimen for Mycobacterium abscessus (MAB) chronic lung disease, a rapidly progressive non-tuberculous...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $426,938 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 23, 2025, with a completion date of May 31, 2027. The award supports the development of a simplified, cost-effective mouse model of chronic Mycobacterium abscessus lung disease using BALB/c mice that requires only weekly cyclophosphamide administration. This...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $427,521 under Project Grant R21AI190702 on May 7, 2026, to identify genetic markers of beta-lactam resistance in Mycobacterium abscessus. The research aims to determine which genes and mutations enable M. abscessus to develop resistance to imipenem and cefoxitin, the primary antibiotics used to treat chronic lung disease caused by this rapidly growing non-tuberculous mycobacterium. M. abscessus...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $195,640 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research integrating genomic and clinical approaches to define and prevent cefiderocol resistance in carbapenem-resistant organisms. The research addresses gaps in understanding cefiderocol resistance mechanisms and clinical use in carbapenem-resistant organisms, which cause severe...
- The National Institute of Allergy and Infectious Diseases awarded Oregon Health & Science University $442,758 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify drug targets in Mycobacterium abscessus through fluorescent probe application. Performance runs through January 31, 2028, in Portland, Oregon. M. abscessus causes the most difficult-to-treat and highest-mortality non-tuberculous mycobacterial pulmonary infections in the United...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $149,190 on January 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support Project Grant F31AI191794, a doctoral fellowship examining mechanisms of antibiotic persistence in a mouse model of systemic infection. The research develops and uses a mouse model of systemic bacterial infection to study how phenotypically distinct bacterial subpopulations survive...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $225,628 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genetic mechanisms of polyene resistance in Candida glabrata using saturating transposon mutagenesis coupled with next-generation DNA sequencing (TN-SEQ). The project will implement TN-SEQ to mutate and barcode every gene in C. glabrata and profile resistance to three approved...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $233,125 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and validate a toolkit for studying 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) as a driver of metabolic adaptation in bacterial pathogens. The research targets bacterial central metabolism as a route to novel antibacterial strategies, focusing on how pathogens remodel their metabolism to...
- The National Institute of Allergy and Infectious Diseases awarded $234,000 to the University of Maryland, College Park on May 26, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research into phagosomal membrane repair pathways during Mycobacterium tuberculosis infection using high-throughput single-cell and single-phagosome analysis. The research deciphers how host cell machinery repairs damage to the mycobacterium-containing vacuole, a process critical...
The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $233,250 for Project Grant R21AI201981 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into cethromycin-based treatment regimens for Mycobacterium avium disease. The study will evaluate whether cethromycin, a next-generation macrolide (ketolide), offers superior efficacy over current standard-of-care multidrug therapies. M. avium is the most common non-tuberculous mycobacterium causing chronic lung disease in the United States, with 5- to 10-year survival rates between 54 and 76 percent. Current treatments rely on prolonged macrolide-based regimens but are undermined by intrinsic resistance, limited drug efficacy, and toxicities associated with available therapies. Specific Aim 1 will identify companion drugs that minimize resistance emergence by systematically evaluating resistance dynamics of cethromycin alone and in combinations under prolonged drug exposure, with emphasis on regimens exhibiting reciprocal suppression of resistance. Specific Aim 2 will assess treatment efficacy in a validated mouse model of chronic M. avium lung disease through pharmacokinetic and pharmacodynamic studies of cethromycin combinations with candidate partner drugs—bedaquiline, ethambutol, and rifampin—measuring bacterial clearance and resistance prevention. Performance will occur in Baltimore, Maryland. The period of performance runs from July 23, 2026 through June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $233.3k | 7/23/26 |