Project Grant R21AI201903
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $571,412 to the University of Maryland, College Park on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the regulation of bacterial physiology and infections through linear diribonucleotides and RNA degradation. The project will characterize how diribonucleases and triribonucleases bind their respective...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $440,908 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify inhibitors of bacterial peptidyl-tRNA hydrolase (PTH). The recipient will synthesize and optimize derivatives of PTH inhibitor compounds with sub-micromolar IC50 values to enhance their activity against Klebsiella pneumoniae PTH and improve cellular uptake. The work includes expanding...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $736,822 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how bacterial lipases drive host immunity and physiology during infection. The research focuses on Staphylococcus aureus lipases, particularly the secreted lipase GEH, which the recipient's laboratory has shown inhibits activation of innate immune cells and blunts pro-inflammatory...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $186,711 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of putrescine biosynthesis and its role in PhoQ signal transduction and magnesium homeostasis in Salmonella typhimurium. The project examines how polyamines and magnesium concentrations are coordinately controlled in bacterial cells and how polyamines substitute for magnesium...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $620,662 on July 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research into mechanisms by which quorum-sensing-active Streptococcus pyogenes suppress innate immune responses in macrophages. The research addresses how GAS strains in a quorum-sensing-on state prevent transcription of pro-inflammatory genes despite activation of upstream NF-κB signaling pathways,...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $698,823 on August 26, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize trojan horse carriers that direct drug import into drug-resistant gram-negative pathogens. The project will identify, characterize, and exploit natural product molecules that conjugate antibiotic payloads to carrier compounds, enabling active transport of antimicrobials...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $549,246 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund Project Grant R01AI192692, which investigates substrate selectivity and regulation of YHAM, a 3'-5' exonuclease in Methicillin-resistant Staphylococcus aureus (MRSA). The research examines how YHAM, an understudied bacterial enzyme required for MRSA virulence, functions through an unusual...
- The National Institute of Allergy and Infectious Diseases awarded the University of Wisconsin–Madison $146,920 on November 30, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research into the molecular mechanisms of bacterial multidrug efflux transporters and antimicrobial resistance. The funded research combines deep mutational scanning with in vivo and in vitro validation to characterize how the NorA efflux transporter exports structurally and...
- The National Institute of Allergy and Infectious Diseases awarded Northern Illinois University $147,766 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 3, 2026. The award funds research investigating how geminivirus viral RNA silencing suppressors (AC2/C2 proteins) subvert the SNRK1/autophagy pathway to suppress host plant antiviral immune responses. The research addresses geminivirus crop disease control by examining defense-counterdefense interactions at...
- The National Institute of Allergy and Infectious Diseases awarded Emory University $161,244 on April 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct experimental evolution assays elucidating evolutionary trajectories to antibiotic resistance in Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and how the immune system modifies these trajectories. The research uses in vivo adaptive laboratory evolution experiments in Galleria...
The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $236,407 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the structural basis of ARMA-mediated resistance to aminoglycoside antibiotics targeting the bacterial ribosome. The research addresses how ARMA methyltransferases confer high-level resistance to aminoglycosides—a cornerstone class of ribosome-binding antibacterial drugs used clinically for over 80 years—through N7-methylation of nucleotide G1405 in 16S rRNA. This single chemical modification abolishes the activity of virtually all 4,6-disubstituted 2-deoxystreptamine aminoglycosides, including gentamicin, tobramycin, and amikacin, while leaving 4,5-aminoglycosides largely unaffected. The project will elucidate whether the prevailing "steric clash" model fully explains ARMA-mediated resistance or whether methylation perturbs local decoding center architecture and interferes with nearby rRNA modifications, causing allosteric changes that weaken drug binding. Performance runs through August 31, 2028, at the University of Illinois's Chicago, Illinois campus (60607). The award is a project grant under the Allergy and Infectious Diseases Research program, which supports biomedical research and research training in infectious diseases at public and private nonprofit institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $236.4k | 8/26/26 |