Project Grant R21AI200873
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $506,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025, with a completion date of June 30, 2027. The award supports the development of high-throughput technologies for generating and screening small interfering RNA (siRNA)-peptide conjugates designed to improve delivery efficiency for viral infection...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Scripps Research Institute a $910,905 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025, with completion targeted for February 12, 2026. This award supports research advancing HIV vaccine development through the application of lipid nanodisc platform technology. The project will develop and characterize engineered transmembrane...
- Federal Grant Award Summary The Scripps Research Institute received a $511,531 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 13, 2026, through January 31, 2031. The primary deliverable is the development and characterization of HIV envelope (ENV) glycoprotein vaccine candidates utilizing a lipid nanodisc platform. The research addresses a critical gap in HIV vaccine...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant of $899,741 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2031. This award supports the development of a long-acting injectable (LAI) therapy for hepatitis B virus (HBV) treatment in individuals co-infected with human immunodeficiency virus (HIV). The research addresses a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $3.02 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning August 8, 2025, with a completion date of July 31, 2029. This award supports the design and development of single-shot sequential immunization regimens for HIV using atomic layer deposition (ALD) technology. The research builds upon preclinical successes...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,935 to the Scripps Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 10, 2025, to identify novel B cell epitopes against human coronaviruses. The research will utilize an integrated platform combining comprehensive characterization, high-resolution structural determination, state-of-the-art multi-bait B cell isolation strategies, and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $184,000 to the Scripps Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. The research project, titled "Proximal Regulation of Innate Immune Signals in Ischemia Reperfusion Injury," focuses on establishing foundational scientific knowledge regarding how the CD14...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant totaling $1,285,304 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and evaluate an enhanced HIV vaccine regimen capable of producing durable broadly neutralizing antibody (BNAB) responses. The research, which commenced August 1, 2025, and extends through July 31, 2030, leverages a novel six-shot germline-targeting...
- Federal Project Grant Award Summary The Scripps Research Institute received a $1,379,954 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 21, 2025, with completion targeted for July 31, 2030. The award supports systematic research to engineer durable immunity through optimization of Human Immunodeficiency Virus (HIV) vaccine parameters designed to drive...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $249,000 Project Grant to the Regents of the University of California at Riverside on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research, which extends through January 31, 2028, focuses on developing novel technologies for single-cell proteoform profiling using top-down mass spectrometry. Proteoforms—molecular forms of proteins...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Scripps Research Institute a $230,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period May 1, 2026 through April 30, 2028. The award supports the development of a modular crosslinking mass spectrometry (XL-MS) platform designed to enable quantitative, proteome-wide mapping of protein-protein interactions (PPIs) in live cells without requiring genetic tagging or in vitro systems. The project delivers a next-generation chemical biology toolkit consisting of three primary research products: (1) a chemically diverse crosslinker library with orthogonal residue reactivity and tunable spacer designs to capture a broader spectrum of interaction interfaces; (2) isotopically encoded variants and optimized workflows enabling quantitative PPI comparison across different biological states; and (3) cleavable enrichment handles permitting gentle, mass spectrometry-compatible peptide recovery. Through systematic benchmarking and application to high-impact biological systems—including small molecule-modulated PPIs and dynamic PPI remodeling during human T cell activation—the research is expected to establish a versatile XL-MS platform and reagent library addressing current limitations in detecting transient, low-abundance, and state-specific protein interactions relevant to therapeutic targeting and drug discovery.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $230.0k | 4/28/26 |