Project Grant R21AI200456
- Federal Project Grant Award Summary Mayo Clinic received a Project Grant award of $443,850 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 4, 2026, with completion scheduled for January 31, 2028. The research project investigates how intestinal exposure to Candida albicans (C. albicans) in early life influences the developing immune system, with particular focus on T cell responses...
- Federal Grant Award Summary Mayo Clinic received a $100,228 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded November 23, 2026, with completion targeted for June 30, 2029. The project develops and evaluates novel biostatistical methods specifically designed to address analytical challenges in human microbiome metagenomic data. The research focuses on improving robustness and...
- Federal Grant Award Summary Mayo Clinic received a $795,316 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 14, 2026 through June 30, 2031. The grant funds research to develop and characterize an improved induced pluripotent stem cell (iPSC) reprogramming system using a modified measles virus vector. The research deliverables include identification of innate immune...
- Federal Grant Award Summary Mayo Clinic received a $441,098 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 23, 2025, with a completion date of June 30, 2027. The research project, conducted at Mayo Clinic's Minnesota facility, investigates the antagonistic actions of IRF4 (Interferon Regulatory Factor 4) and BACH2 (BTB Domain and CNC Homolog 2) transcription...
- Federal Project Grant Award Summary Mayo Clinic received a $441,100 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award supports research focused on developing in vivo Ebola virus (EBOV) life cycle modeling systems under biosafety level-2 (BSL-2) conditions. The research objectives include generating two murine models to...
- Federal Grant Award Summary The J. David Gladstone Institutes received a $2.05 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 11, 2026, with completion targeted for April 30, 2031. The PHAIGE (Phage AI-Guided Engineering) Therapy Center will develop next-generation preclinical assays, computational tools, and translational frameworks to accelerate bacteriophage...
- Federal Project Grant Award Summary Mayo Clinic Arizona, a nonprofit academic medical center and research institution, received a $486,109 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective July 1, 2025, through June 30, 2027, supports investigator-initiated biomedical research examining Type 2 immune responses in endotoxemia-induced lung injury. The research project...
- Federal Grant Award Summary Mayo Clinic received a $689,081 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2031. The award funds research to establish the etiology of chronic placental villitis of unknown etiology (VUE), an inflammatory placental condition characterized by maternal CD8+ T cell infiltration into chorionic villi. The...
- Federal Grant Award Summary Princeton University's Office of Research and Project Administration received a $451,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 23, 2025, with completion targeted for June 30, 2027. The research initiative employs chemical synthetic lethality methodology to identify novel antimicrobial targets in gram-negative bacterial...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,850 to the Whitehead Institute for Biomedical Research on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a five-year project (through January 31, 2031) investigating how apicomplexan parasites, such as Toxoplasma and Plasmodium, recognize and invade host cells. The research deliverables include peer-reviewed publications and...
Mayo Clinic received a $441,100 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 13, 2026, with completion targeted for June 30, 2028. The award funds research directed at understanding phosphoglucomutase (PGM) as a potential therapeutic target in Pneumocystis pneumonia (PJP), a significant opportunistic infection in AIDS patients. The research will deliver scientific findings on PGM's role in Pneumocystis cell wall synthesis, viability, and pathogenesis through experimental evaluation of PGM enzyme activity, assessment of selective PGM inhibitors on organism growth and cell wall integrity, and transcriptional and biochemical analyses using complementary yeast models. The grant supports basic research aimed at identifying PGM as a druggable target distinct from human homologs, leveraging prior evidence that the small-molecule inhibitor ISFP10 selectively reduces fungal PGM activity with minimal impact on human isoforms. Deliverables include characterization of Pneumocystis PGM function, global transcriptional responses to PGM inhibition, and assessment of cell wall carbohydrate composition and organism viability—outputs intended to establish the scientific rationale for PGM-targeted antimicrobial development as a treatment strategy for this serious AIDS-related infection.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.1k | 7/13/26 |