Project Grant R21AI200131
- Federal Grant Award Summary Duke University's Office of Research Administration received a Project Grant award of $806,623 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 29, 2026, with completion targeted for April 30, 2027. The award supports structural and kinetic research aimed at elucidating the association transition states and intermediates governing HIV-1 broadly neutralizing...
- Federal Project Grant Award Summary Duke University received a $423,236 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2027. The award funds research to characterize a novel hypoxia-responsive cell-cycle checkpoint in Cryptococcus neoformans, a pathogenic budding yeast. The research will elucidate the mechanisms by which low oxygen (O₂)...
- Federal Project Grant Award Summary Duke University's Office of Research Administration has received a $829,735 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with completion targeted for March 31, 2031. This research initiative focuses on the discovery and optimization of broadly protective neutralizing antibodies against Merbecovirus (MERB), a genus of...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $106,164 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2028. This award supports investigator-initiated research examining the role of HLA-E-VL9 (Human Leukocyte Antigen-E complexed with a conserved viral peptide) and related antibodies in...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $171,269 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective November 1, 2025, with completion targeted for April 30, 2028. This award funds biomedical research aimed at investigating the role of the RGS12 locus in regulating macrophage function and identity, particularly within...
- Federal Grant Award Summary Duke University received a $203,556 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 3, 2026, with a completion date of March 31, 2031. This K24 Midcareer Investigator Award supports mentoring activities in clinical pharmacology and pharmacometrics focused on anti-infective drug optimization. The primary deliverable is the development and...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $783,701 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 22, 2026, through April 30, 2031. The grant supports investigator-initiated research to elucigate the mechanisms governing B cell evolution and plasma cell differentiation in the context of broadly neutralizing antibody...
- Federal Project Grant Award Summary Duke University received a $807,498 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on August 8, 2025, with completion targeted for July 31, 2030. The grant supports research to elucidate the evolution and pathogenic mechanisms of Cryptococcus neoformans strains isolated from HIV/AIDS patients with cryptococcal meningitis (CM). The research...
- Federal Grant Award Summary Duke University received a $3,012,181 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 10, 2025, with completion targeted for August 31, 2029. The grant supports research investigating dietary fiber-microbiome interactions to elucidate mechanisms for suppressing multi-drug resistant organisms (MDROs)—specifically Clostridioides...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with completion targeted for January 31, 2028. The project focuses on developing prognostic biomarkers for invasive candidiasis through examination of host gene expression patterns in circulating immune...
Duke University received a $237,831 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 22, 2026, with completion targeted for April 30, 2028. The research project, conducted at Duke's Durham, North Carolina facility, investigates the role of MESH1 protein in regulating RNA sensing through nucleotide metabolism. The research will produce biochemical characterization and structural analysis of MESH1's phosphatase activity on 3-phosphoadenosine 5-phosphate (PAP), including enzymatic kinetics and co-crystal structures, as well as comparative analysis with the BPNT1 phosphatase across cellular compartments relevant to innate immune sensing. The project will also deliver experimental findings on how MESH1 and PAP metabolism influence innate immune responses to RNA-based danger signals, including viral infection and synthetic RNA ligands, using genetically modified cells. This basic science research aims to elucidate mechanisms by which MESH1 protects cells from PAP-induced dysregulation of RNA decay and inappropriate immune activation, contributing to fundamental understanding of immune tolerance and antiviral defense mechanisms.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $237.8k | 5/26/26 |