Project Grant R01AI189300
- This $616,588 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand the molecular function of unstudied genes in the fungal pathogen Cryptococcus neoformans, a leading cause of fungal meningitis. The research team at the University of California, San Francisco constructed and phenotypically profiled a comprehensive gene deletion collection for C. neoformans to elucidate the...
- This federal Project Grant award in the amount of $423,236 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to characterize a novel hypoxia cell-cycle checkpoint in the pathogenic yeast Cryptococcus neoformans. The key objectives are to: 1) analyze changes in cell-cycle events as Cryptococcus cells transition from log-phase growth to saturation arrest, 2)...
- This federal Project Grant award of $158,433 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Clemson University. The grant supports research to identify the metabolic mechanisms that allow the pathogenic fungus Cryptococcus neoformans to tolerate high levels of carbon dioxide, which is a key virulence trait enabling this fungus to cause severe and often fatal infections in humans. The...
- This Project Grant award, valued at $232,073 and awarded on November 12, 2024, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The research project aims to explore the impact of Cryptococcus neoformans (CN) replicative aging on infection in AIDS patients, particularly the host-pathogen dynamics in microglia co-infected with CN and HIV-1. The project will investigate the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $470,028 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University (NYU) to conduct research on deciphering fungal pathogen-specific cell cycle mechanisms in order to fuel antifungal drug discovery. The 5-year grant, with a period of performance from August 21, 2025 to July 31, 2030, will focus on investigating two promising fungal cell cycle variations in the...
- This Project Grant award of $749,594, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the role of the host sphingosine kinase 1 (SK1) pathway in controlling infection by the fungus Cryptococcus neoformans during immunodeficiency. The award recipient, The Research Foundation for the State University of New York (RFSUNY) doing business as Stony Brook University, will...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $515,875 over approximately 5 years to the University of Florida to conduct research on the mechanisms underlying Cryptococcus neoformans-induced meningoencephalitis and neurotoxicity in a CD4 T cell-deficient mouse model. The key objectives are to: (1) determine how the Cryptococcus neoformans capsular...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), is supporting research to elucidate the biosynthesis of beta-1,6-glucan, a key component of the cell wall in the fungal pathogen Cryptococcus neoformans. The $773,053 award to The Washington University aims to determine how the GGT2 glycosyltransferase enzyme affects the structure and integrity of the cryptococcal...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $556,375 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the J. Craig Venter Institute, Inc. (JCVI) to identify the genetic pathways that govern thermoadaptation and virulence traits in the fungal pathogen Histoplasma capsulatum. This research aims to understand the mechanisms that allow Histoplasma, a dimorphic fungus, to sense changes in human body temperature and...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $4,874,388 Cooperative Agreement to Duke University on June 13, 2025. The award will fund the "Center for Multiscale Immune Systems Modeling - The Center of Excellence (COE)", a research initiative that brings together experts to develop innovative solutions for multi-scale modeling in infectious and immune-mediated...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $807,498 to Duke University to conduct research on the evolution and characteristics of the fungal pathogen Cryptococcus neoformans, which causes deadly central nervous system infections in HIV/AIDS patients. The key objectives are to: 1) build a comprehensive collection and genomic database of over 3,000 global C. neoformans isolates; 2) develop high-throughput phenotyping and animal model screening capabilities to link genomic data to virulence traits; and 3) leverage these insights to improve diagnostic capabilities and treatment strategies for cryptococcal meningitis. The project will be performed at Duke University in Durham, North Carolina over the period of August 8, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $807.5k | 8/12/25 |