Project Grant R21AI199487
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Maryland, College Park $722,262 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and validate a novel microneedle-array technology for promoting antigen-specific immune tolerance in autoimmune diseases. The research addresses critical limitations in existing autoimmune therapies—such as broad immunosuppression,...
- Federal Grant Award Summary Drexel University received a $152,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 16, 2025, with completion targeted for June 30, 2027. The research project, titled "Placating Death Eaters: Tuning Macrophage Metabolism and Phenotype via Nanoparticles," develops cyclodextrin nanoparticles (CDNPs) as a delivery mechanism to modulate...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $431,750 to the University of California, Irvine on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project concluding January 31, 2028. The research focuses on functional expansion of regulatory T cells (Tregs) to limit central nervous system (CNS) autoimmunity. The project investigates key principles for expanding Tregs to...
- Federal Grant Award Summary Vanderbilt University received a $448,089 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and test a novel tolerogenic immunotherapy platform for treating autoimmune diseases. The award, effective February 3, 2026 through January 31, 2028, supports research focused on engineering extracellular vesicles (EVs)—small membrane-bound particles secreted...
- Federal Project Grant Award Summary The University of Michigan has received a $516,410 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 23, 2026, with a completion date of March 31, 2031. The award funds the development of precision biomaterials designed to monitor and enrich antigen-specific immune cells in vivo, addressing a critical gap in current immunological...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Michigan a $425,226 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 25, 2025, with a completion date of May 31, 2027. This research project investigates the engineering of trained innate immunity using biomaterial implants to establish feasibility and control systemic immune responses. The primary...
- Federal Grant Award Summary Emory University received a $100,228 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded November 18, 2026, with completion targeted for June 9, 2029. The award supports research investigating autoreactive B cell activation mechanisms in autoimmune disease, specifically examining the extrafollicular (EF) pathway of B cell differentiation in a TLR7...
- Federal Project Grant Award Summary San Diego State University Research Foundation received a $121,770 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded November 26, 2026, with completion targeted for May 27, 2028. The project, "Leveraging Hydroides Elegans to Uncover NFκB Pathway Roles in Innate Immune Discrimination," delivers fundamental research into how the...
- Federal Project Grant Award Summary The University of Southern California received a $166,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 5, 2025, with completion scheduled for May 31, 2027. This grant supports the development of novel tools for precision targeting of pro-autoimmune Th17 cells to address autoimmune diseases affecting over 23 million Americans. The...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Columbia University's Health Sciences Division a Project Grant totaling $452,375 (awarded February 6, 2026, with completion targeted for January 31, 2028) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports in vivo profiling and immunological characterization of Chimeric Autoantibody Receptor T Cell (CAART) therapy in a first-in-human clinical trial...
Award Summary Drexel University received a $222,786 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 24, 2026, with an ultimate completion date of May 31, 2028. The award funds development of injectable acellular hydrogels designed to provide local immunoregulation and restore immune tolerance in autoimmune disease patients. The research addresses a critical gap in current autoimmune therapies by engineering a granular hydrogel conjugated with B7X, a co-inhibitory immune checkpoint molecule, to localize regulatory T cell (Treg) induction while simultaneously suppressing pro-inflammatory T cell differentiation. The hydrogel employs azide-alkyne click chemistry to covalently tether B7X, enabling controlled local delivery that circumvents limitations of systemic immunosuppression and avoids off-target effects associated with conventional soluble factor delivery and adoptive cell transfer approaches. The research deliverables include characterization of the hydrogel formulation, validation of B7X bioactivity following chemical modification, and preclinical efficacy data demonstrating enhanced local Treg abundance and symptomatic mitigation in mouse models of autoimmune disease. This project-based funding supports the translational development pathway from basic immunological mechanisms to a potentially curative therapeutic intervention that could establish antigen-specific self-tolerance, representing a significant advance over current palliative immunosuppressive treatments for the 15 million Americans with autoimmune conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $222.8k | 6/25/26 |