Project Grant R21AI199018
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $122,472 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Children's Hospital on August 13, 2025, with a completion date of July 31, 2027. This award supports investigator-initiated research aimed at elucidating the molecular mechanisms underlying the activation and regulation of the NLRP3 inflammasome, a critical component of the...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $445,000 project grant effective February 18, 2026, through January 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports investigator-initiated research into novel immunoregulatory mechanisms that modulate myeloid trained immunity following organ transplantation. The research focuses on elucidating how semaphorin 3F...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $522,524 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, with a completion date of June 30, 2030. This award supports research into the mechanism of inflammation in adenosine deaminase 2 (ADA2) deficiency (DADA2), a rare inborn error of immunity characterized by systemic inflammation, vascular involvement,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $800,557 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 19, 2026, with a completion date of January 31, 2031. This research initiative focuses on identifying mechanisms by which the pathogen Staphylococcus aureus manipulates inflammasome activities critical to host defense. The project addresses a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital $151,040 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 4, 2025, to support a project extending through July 31, 2028. This Project Grant funds basic science research investigating the regulatory mechanisms of a small regulatory RNA (sRNA) designated BECO in Pseudomonas aeruginosa, a gram-negative bacterium that causes serious...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $489,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 24, 2025, with a completion date of June 30, 2027. The award funds structural research aimed at determining the high-resolution three-dimensional structure of the full-length nucleocapsid (N) protein of Severe Acute Respiratory Syndrome Coronavirus 2...
- Federal Grant Award Summary Award Details: The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant totaling $889,519 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award commenced April 1, 2026, with a completion date of March 31, 2031. Products and Services: This research initiative focuses on developing a multi-biologic, adeno-associated virus (AAV)-deliverable approach toward an HIV-1 functional...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant to The Children's Hospital Corporation (Boston Children's Hospital) on July 9, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Overcoming Obstacles in Structural Elucidation of B Cell Antigen Receptor Assembly and Lateral Interaction," will be conducted through June 30, 2027, in Massachusetts. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $716,281 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Children's Hospital, with an award date of July 24, 2025 and completion date of June 30, 2030. This research project investigates the mechanisms by which T regulatory cells (Tregs) control allergic skin inflammation, with particular focus on how deficiencies in the DOCK8 protein...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $647,187 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 3, 2025, with a completion date of June 30, 2030. The award supports biomedical research investigating the novel role of heme synthesis in controlling regulatory T cell (Treg) fitness and function. The research focuses on...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $267,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms of AIRE (Autoimmune Regulator) in transcriptional regulation. The research, with an award date of April 16, 2026 and completion date of March 31, 2028, will generate scientific knowledge addressing how AIRE protein engages peripheral tissue antigen (PTA) loci and activates their transcription in medullary thymic epithelial cells. The research will elucidate the mechanistic relationship between two distinct categories of AIRE target genes, with particular focus on understanding how AIRE-P300/CBP condensates directly activate transcriptionally silent PTA genes through transient molecular interactions. Findings from this research are intended to advance understanding of immune tolerance mechanisms and inform therapeutic approaches to autoimmune polyglandular syndrome type 1 (APS-1), a primary immune deficiency disease resulting from AIRE defects. The project will be conducted at Boston Children's Hospital in Boston, Massachusetts, a nonprofit pediatric teaching hospital and research institution affiliated with Harvard Medical School with extensive experience managing federal research funding across multiple NIH institutes and federal agencies. Deliverables will include peer-reviewed scientific publications documenting experimental methodologies, mechanistic findings, and comparative analyses of Group-1 and Group-2 AIRE target gene activation pathways, contributing to the broader body of knowledge on immunological mechanisms and transcriptional regulation relevant to infectious diseases and immune-mediated conditions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $267.0k | 4/17/26 |