Project Grant R21AI197893
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $790,946 to the Trustees of Indiana University (Indiana University Indianapolis) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct biomedical research investigating dysregulation of humoral immunity following Plasmodium infection. The award, obligated on February 10, 2026, with an ultimate completion date of January 31, 2031, supports a five-year...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Indiana University Indianapolis $781,241 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 5, 2025, for a project extending through July 31, 2030. This Project Grant supports a systems analysis to understand the differential pharmacokinetics and protective efficacy of anti-malarial monoclonal antibodies (MAbs) in clinical field trials. The research leverages...
- Federal Grant Award Summary Indiana University, through its Indianapolis campus, received a $2.27 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 22, 2025. This award funds a five-year research initiative examining post-tuberculosis lung disease (PTLD) in youth aged 15-24 with and without HIV across multiple African countries. The project leverages the Tuberculosis Sentinel...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $162,000 Project Grant award dated June 18, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, concluding May 31, 2027, investigates the critical and opposing roles of transforming growth factor beta (TGFB) signaling in T follicular helper (TFH) cells and mast cells (MC) in allergic disease...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases awarded a Project Grant of $454,036 to the University of California, Irvine under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective May 1, 2025 through April 30, 2027. The award supports investigator-initiated biomedical research examining the role of microglia—brain-resident immune cells—in defending against Toxoplasma gondii infection, particularly in the context of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Massachusetts a $412,581 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. This research initiative focuses on investigating specialized mitochondrial deoxyribonucleic acid (DNA) polymerases in African trypanosomes to advance understanding of kinetoplast DNA (kDNA) replication mechanisms....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $435,875 to the University of California, Merced under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 18, 2025, for a project period extending through June 30, 2027. This Project Grant funds investigator-initiated biomedical research focused on understanding the role of the NFKBID gene and its encoded protein IKBNS in generating protective humoral...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Indiana University Indianapolis a Project Grant totaling $433,303 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 18, 2025, with a completion date of May 31, 2027. The award funds research and development of an innovative mosquito control technology utilizing RNA interference (RNAi)-based gene silencing to combat mosquito-borne infectious diseases. The primary...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a $1.73 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 29, 2025, through July 31, 2029. This research project investigates the mechanisms by which microglial interferon-gamma (IFN-γ) production coordinates innate and T cell-mediated immune responses to prevent toxoplasmic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,850 to the Whitehead Institute for Biomedical Research under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 20, 2026, for a project extending through January 31, 2031. This Project Grant supports biomedical research investigating how apicomplexan parasites recognize and invade host cells—a critical mechanism for understanding parasitic infections that...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Indiana University Indianapolis a Project Grant totaling $384,939 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 9, 2026, with completion targeted for January 31, 2028. The project investigates mechanisms driving reactivated toxoplasmosis in HIV/AIDS co-infection, specifically examining how latent Toxoplasma gondii bradyzoites convert into replicative tachyzoites. The research leverages translational control as a central mechanism, focusing on TGIF2A (Tax-binding protein-101-interacting factor 2A) phosphorylation and the identification of preferentially translated messenger RNAs (mRNAs) essential for parasite reactivation. Deliverables include determination of TGIF2A dephosphorylation mechanisms during reactivated toxoplasmosis and identification of critical mRNAs central to recrudescent infection, with findings expected to advance understanding of this serious opportunistic infection affecting immunocompromised populations. A sub-award to the University of Missouri at Kansas City (UMKC) Holmes Laboratory supports Aim 2 of the project, executing experimental and computational components focused on translational reprogramming during bradyzoite-to-tachyzoite transition. UMKC will deliver ribosome profiling (Ribo-seq) analysis, matched RNA-sequencing data, bioinformatic analysis of translation efficiencies across reactivation time points, and validation of prioritized candidate transcripts. These technical deliverables directly support identification of the molecular factors driving parasite reactivation in AIDS-related toxoplasmosis.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.9k | 2/9/26 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
10763S | The Curators Of The University Of Missouri | Project Grant R21AI197893 | $80.9k | 3/9/26 |