Project Grant R21AI196939
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Irvine a Project Grant of $263,892 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025 through July 31, 2026. This award supports research on oral N-acetylglucosamine (GlcNAc) as an anti-neuroinflammatory add-on therapy for multiple sclerosis (NANA-MS). The research will advance understanding of how GlcNAc...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $150,104 to the University of California, Irvine under the Allergy and Infectious Diseases Research program (CFDA 93.855) on January 16, 2026, with a completion date of August 31, 2027. This award funds research investigating the role of cystatin F (CST7) expression on microglia in constraining demyelination following viral infection of the central nervous system....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases awarded $454,036 to the University of California, Irvine under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective May 1, 2025 through April 30, 2027. This Project Grant funds biomedical research investigating the role of microglia in immune defense during Toxoplasma gondii infection, particularly in the context of human immunodeficiency virus (HIV)/acquired immunodeficiency...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Irvine $2,832,747 through the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 14, 2025, for a project titled "Metabolic Regulation by SAPS3 of Virus-Specific T Cell Immunity." The four-year project, scheduled for completion by June 30, 2029, will conduct biomedical research to investigate how the serine/threonine-protein...
- Federal Project Grant Award Summary The University of California, San Diego received a $3,022,197 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 8, 2025, with a completion date of June 30, 2029. The research focuses on investigating the regulatory T cell (Treg)-Interleukin-27 (IL-27) axis in immune regulation, specifically examining how Treg cell-derived IL-27...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,202 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, Berkeley, effective June 12, 2025, with completion targeted for May 31, 2027. This research award supports investigator-initiated biomedical research focused on understanding the mechanisms of immune regulation relevant to both autoimmune...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Diego a Project Grant totaling $183,604 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct biomedical research on tissue-resident memory T cells. The award, effective May 13, 2025, with completion targeted for November 30, 2027, supports investigator-initiated research examining the role of T Cell Factor 1 (TCF1), a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $431,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Irvine for a two-year developmental project running from July 1, 2025 through June 30, 2027. This award supports the development of a basic immunological toolbox for the genus Peromyscus, specifically addressing critical research gaps in studying white-footed...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded UC San Diego a Project Grant of $159,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period July 1, 2025 through June 30, 2027. The award supports the development and validation of a novel transgenic mouse model designed to measure T cell receptor (TCR) signal strength in dual TCR-expressing cells. Specifically, the research will generate and validate a...
- Federal Grant Award Summary The University of California, San Diego received a $3,194,992 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 16, 2025, with a completion date of June 30, 2029. The grant supports biomedical research investigating the roles and regulation of tissue-resident CD8 T cells during persistent viral infection, utilizing a mouse model of chronic...
The University of California, Irvine received a $431,750 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 1, 2026, through January 31, 2028. This award supports research investigating the functional expansion of regulatory T cells (Tregs) to limit central nervous system (CNS) autoimmunity. The research utilizes advanced imaging technologies and immunomodulatory biologics to examine the combinatorial activation of T cell receptor, interleukin-2 signaling, and transforming growth factor-beta signaling in vivo, with the objective of identifying key principles for expanding Tregs to limit CNS autoimmune pathophysiology and promote myelin repair. The project deliverables include characterization of target engagement, biodistribution, and immunosafety of Treg-expanding biologics using an experimental autoimmune encephalomyelitis model of multiple sclerosis-like disease (Aim 1), and definition of cellular and molecular determinants of Treg expansion. This research addresses a critical gap in therapeutic approaches for autoimmune disorders by developing targeted immune regulation strategies that avoid generalized immunosuppression, with potential applications in restoring neuronal function and improving quality of life for patients with CNS autoimmune conditions. The work will be conducted at UCI's Irvine, California facility.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 1/29/26 |