Project Grant R21AI196865
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College, operating through Harvard T.H. Chan School of Public Health, $149,163 on September 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Assistance Listing designation F31AI197660). The award funds identification of essential reticulocyte host receptors for Plasmodium vivax invasion using biochemical and functional genomic approaches. The research employs...
- The National Institute of Allergy and Infectious Diseases awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $506,415 on February 9, 2026, for research on pre- and post-exposure prophylaxis of tick-transmitted babesiosis using the antimalarial drug tafenoquine under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research evaluates tafenoquine's potential to prevent Babesia microti infection transmitted by Ixodes scapularis nymphs. The...
- The National Institute of Allergy and Infectious Diseases awarded the University of Vermont & State Agricultural College $176,094 on June 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop imidazopyridine-containing compounds as therapeutics for babesiosis. The project pursues hit-to-lead development of a series of 28 imidazopyridine-containing compounds identified as potent in vitro growth inhibitors of Babesia duncani, with EC50 values as low as...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $463,375 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover antimicrobial metabolites produced by human gut bacteria through high-throughput screening. The research will screen a library of gut bacterial culture and supernatant extracts for growth-inhibitory activity against a panel of bacterial and fungal pathogens and pathobionts...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Tufts University School of Medicine a $165,000 project grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 1, 2025, with a completion date of June 30, 2027. This award funds the development of an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the causative agent of Lyme disease. The primary deliverables...
- The National Institute of Allergy and Infectious Diseases awarded Northeastern University $100,228 on December 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of G-quadruplex DNA structures in the antigenic variation mechanism of Borrelia burgdorferi, the causative agent of Lyme disease. The research addresses the molecular mechanism by which B. burgdorferi evades host adaptive immune defenses through antigenic variation—reshaping outer...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from August 1, 2025, through July 31, 2027. The award supports the development and adaptation of an innovative in vitro organotypic human skin model designed to enable tick feeding and study the transmission and colonization of Borrelia...
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College $655,345 on September 19, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support trainee stipends, tuition, and related costs for eight second- and third-year doctoral students in the Harvard Graduate Program in Bacteriology (GPIB). The GPIB trains PhD students recruited from the Biological and Biomedical Sciences parent program at Harvard Medical...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Tufts College (doing business as Tufts University School of Medicine) $859,278 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to accelerate discovery of narrow-spectrum antibiotics targeting Borrelia burgdorferi, the causative agent of Lyme disease. Narrow-spectrum agents that affect only the target bacterium avoid resistance propagation in off-target bacteria, microbiome...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $835,269 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on cytokine regulation of lymphocyte trafficking. The project investigates how high endothelial venules (HEV)—specialized microvessels in secondary lymphoid organs—form and function, with emphasis on the role of endothelial CD130 signaling in HEV formation and...
The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) $228,000 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI196865). The award funds therapeutic repurposing research to identify new treatment options for human babesiosis, a tick-borne parasitic disease transmitted alongside Lyme disease that has more than doubled in incidence over the past 15 years in the United States. The research leverages a high-throughput chemical screen of approximately 6,800 compounds, including FDA-approved drugs and clinical-stage compounds already validated for human safety, to identify inhibitors of babesiosis parasite proliferation. The work addresses a critical therapeutic gap: existing babesiosis drugs are repurposed from malaria research and exhibit poor efficacy and vulnerability to resistant parasites, while no vaccine exists for the disease. The performance period runs through July 31, 2028, with work performed in Boston, Massachusetts. The award is a Project Grant, a mechanism under the NIAID research program designed to support innovative research addressing emerging health threats in infectious diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $228.0k | 8/11/26 |