Project Grant R21AI196817
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Applied Biomedical Science Institute a Project Grant of $976,318 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 6, 2026, with a project completion date of March 31, 2031. The award funds research to elucidate the molecular mechanisms underlying the cow immune system's production of ultralong complementarity-determining region H3 (CDR H3) antibodies—a unique...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $843,182 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 16, 2026, with completion scheduled for March 31, 2031. This five-year research initiative investigates the determinants of viral assembly and infectivity within the Ebola virus VP24 protein, specifically examining how this multifunctional...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $451,000 to the University of California, San Francisco under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 15, 2025, with completion scheduled for July 31, 2027. This Project Grant supports the development and application of high-resolution phage immunoprecipitation sequencing (PhIP-Seq) arrays designed to comprehensively evaluate antibody responses to...
- Federal Grant Award Summary Boston University Medical Campus received a $204,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. The award funds investigator-initiated research aimed at understanding the mechanisms of filovirus messenger RNA (mRNA) translation, with particular focus on Ebola virus. The project deliverables include...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pennsylvania $446,875 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 16, 2025, for a project extending through August 31, 2027. This Project Grant funds investigator-initiated biomedical research aimed at advancing understanding of filoviral pathogenic mechanisms and identifying novel antiviral targets. The research specifically examines...
- Federal Grant Award Summary The University of Pennsylvania received a $480,249 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2027. This award supports research investigating the extracellular matrix (ECM) as a determinant of filovirus infectivity, specifically examining how ECM composition and stiffness influence Ebola virus (EBOV) and Marburg...
- Federal Project Grant Award Summary Mayo Clinic received a $441,100 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award supports research focused on developing in vivo Ebola virus (EBOV) life cycle modeling systems under biosafety level-2 (BSL-2) conditions. The research objectives include generating two murine models to...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $566,875 to the La Jolla Institute for Immunology under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 18, 2026, with a completion date of January 31, 2028. Under this Project Grant, the institute will conduct research to de-orphanize a novel G-protein coupled receptor (GPCR) expressed by tissue-resident memory T cells (TRM cells). The research objective...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Washington University a $777,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This award funds research titled "Advancing Lymphatic Filariasis Elimination with Parasite Genomic Epidemiology," which will deliver comprehensive genomic analysis and characterization of Wuchereria bancrofti...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $899,850 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Whitehead Institute for Biomedical Research, effective February 20, 2026, through January 31, 2031. This award supports fundamental research aimed at elucidating the molecular mechanisms by which apicomplexan parasites recognize and invade host cells—a critical process for parasite survival...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $279,000 Project Grant to the La Jolla Institute for Immunology from April 1, 2026, through March 31, 2028, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award funds detailed analysis of antibody repertoires in multiply-exposed individuals from the Democratic Republic of the Congo who demonstrate extraordinarily broad humoral immune responses against multiple filovirus species, including all four pathogenic orthoebolaviruses (Ebola, Bundibugyo, Sudan, and Taï Forest viruses) and both orthomarbugviruses (Marburg and Ravn viruses). The research will characterize polyclonal antibody reactivity patterns to identify broadly neutralizing monoclonal antibodies with cross-protective potential against diverse filoviruses. This research addresses a critical gap in filovirus therapeutics by leveraging a unique cohort of 23 serology-confirmed individuals with broad filovirus exposure histories—a population substantially different from previously studied single-exposure survivors. The deliverables from this project are expected to advance the discovery and development of broadly neutralizing monoclonal antibody treatments and vaccine candidates capable of protecting against multiple filovirus species, thereby enhancing preparedness for unpredictable filovirus outbreaks in endemic regions and reducing infection risk for residents, military personnel, aid workers, and travelers in Central and West Africa.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $279.0k | 4/1/26 |