Project Grant R21AI196204
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $657,673 to the Regents of the University of Minnesota under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 22, 2025, for a five-year research project concluding June 30, 2030. This Project Grant funds research investigating non-deletional CD8+ T cell tolerance mechanisms, which are critical to understanding how the immune system prevents autoimmune disease....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota $181,928 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 30, 2025, with a completion date of June 30, 2026. This project grant supports basic immunological research investigating the mechanisms by which extracellular damage sensors ARTC2 and P2RX7 regulate CD8+ tissue resident memory T cell (TRM) homeostasis....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $171,096 to the Regents of the University of Minnesota on May 29, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support investigative research on bystander CD8+ T cell-mediated immunopathology. The project, with completion anticipated by August 23, 2027, focuses on elucidating the mechanisms by which dysregulated bystander memory CD8+ T cells...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $231,000 to the Regents of the University of Minnesota under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 1, 2025, with completion targeted for July 31, 2027. The University of Minnesota will conduct advanced structural and molecular research to elucidate the mechanisms of human immunodeficiency virus type 1 (HIV-1) cell-to-cell transmission in primary T...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $450,462 to the Regents of the University of Minnesota on August 13, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support basic research investigating the mechanisms of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) in transcription regulation. The research project, which extends through May 31, 2030, will elucidate how EBNA2 regulates gene...
- Federal Project Grant Award Summary The University of Minnesota's Office of Sponsored Projects Administration received a $180,617 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 26, 2025, with a completion date of December 31, 2026. This research initiative, conducted in Minneapolis, Minnesota, investigates the role of Sphingosine-1-Phosphate Receptors (S1PRs) and...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota $720,588 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 1, 2025, for a five-year project period extending through July 31, 2030. This Project Grant supports the development of broadly protective vaccines against New World arenaviruses, which cause severe hemorrhagic fevers and other serious diseases in...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $136,988 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Maryland, Baltimore on August 20, 2025, with a completion date of July 31, 2027. This award funds biomedical research aimed at understanding the dual role of transcription factor EB (TFEB) in regulating both proviral and antiviral autophagy during Enterovirus D68...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota a $713,107 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular determinants and vulnerabilities of HIV-1 cell-to-cell transmission. The award, effective February 20, 2026, and concluding January 31, 2031, supports basic science research examining how HIV-1 spreads between infected...
- Federal Project Grant Award Summary The University of Pittsburgh received a $691,788 Project Grant award dated July 25, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, with an ultimate completion date of June 30, 2030, supports investigator-initiated biomedical research focused on understanding and controlling the Epstein-Barr virus (EBV) life cycle in B cell and epithelial cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded $224,368 to the Regents of the University of Minnesota under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 13, 2026, with a completion date of January 31, 2028. This Project Grant supports biomedical research focused on identifying host cellular factors essential for Epstein-Barr Virus (EBV) episome persistence and maintenance within infected cells. The research deliverables include conducting a genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) screen using a novel EBV episome monitoring system to systematically identify host factors critical for viral genome maintenance, and determining the protein composition of complexes formed between the viral protein EBNA1 and host cellular factors that facilitate EBV persistence. The research outcomes are designed to generate novel therapeutic targets for EBV eradication and treatment of EBV-associated diseases, including infectious mononucleosis, nasopharyngeal carcinoma, post-transplantation lymphoproliferative disorder, and AIDS-related lymphomas. By identifying previously unexplored host cellular factors essential for viral episome maintenance, this project aims to address a critical gap in therapeutic options for EBV-related conditions and provide a scientific foundation for developing targeted intervention strategies where current treatment options remain limited.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $224.4k | 2/12/26 |