Project Grant R21AI191967
- This federal Project Grant award of $603,338 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the HIV-1 virus mediates membrane fusion and entry into host cells. The research will use cryo-electron tomography and molecular dynamics simulations to investigate the structural interactions between the HIV-1 envelope glycoprotein, CD4 receptor, and co-receptors on cell...
- This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to better understand the molecular mechanisms of HIV spread through cell-cell contact across a virological synapse (VS). The $515,282 award will enable Case Western Reserve University (CWRU) to develop a novel flow cytometry assay for quantifying and purifying infected cell-target cell pairs, and leverage...
- The University of Chicago was awarded a $295,276 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to develop a mechanistic understanding of viral assembly, maturation, and uncoating processes, which could aid in the design of new antiretroviral therapies targeting...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $479,925 to support research on the mechanisms by which HIV-1 infection induces the production of type I interferons (IFNs) in human immune cells. The project aims to investigate whether cell-to-cell transmission of HIV-1, rather than cell-free viral infection, is a key driver of IFN activation through...
- The Thomas Jefferson University, through its Sidney Kimmel Medical College, received a $458,326 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study the function of the HIV-1 envelope glycoprotein cytoplasmic tail domain and its impact on viral trafficking and transmission. The research aims to uncover new targets for antiviral drug development, which remains critical as the AIDS pandemic continues....
- This federal Project Grant award of $188,208, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855), supports research to mechanistically investigate how retroviruses like HIV integrate their viral DNA into the chromatin of host cells. The proposed work will employ novel nucleosome reconstitution, biochemical assays, and cryo-electron microscopy to examine the preferred binding and integration...
- This Project Grant award of $856,202 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), which oversees the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The award will fund a 5-year study led by researchers at the University of California, San Francisco (UCSF) to investigate the role of IL-10 and IFN signaling in controlling the HIV reservoir and achieving functional HIV cure. The project aims to determine if enhancing IL-10 and...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
- This $118,488 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on January 20, 2025, supports research to develop HIV-resistant hematopoietic stem cells through targeted base editing. The project aims to identify genetic mutations in the CCR5 and CXCR4 co-receptors that can prevent HIV entry into CD4 cells while maintaining the central functions of these proteins in hematopoiesis. The research involves...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) provides $156,160 to Northwestern University to study the structural basis of HIV accessory proteins VPR and VIF. The goal is to contribute to understanding and potentially combating the HIV/AIDS pandemic through structural biology research. The award period runs from September 1, 2025 to August 31, 2027. The...
This federal Project Grant award of $231,000.00, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), supports research to investigate the structural architecture and molecular mechanisms of HIV-1 cell-to-cell transmission. The project aims to use advanced cryoimaging techniques to explore the ultrastructure of HIV-1 transmission in primary T lymphocytes, with the goal of improving understanding of how cell-to-cell transmission enables the evasion of antiretroviral therapies and immune responses. The award was granted to the Regents of the University of Minnesota, a prominent 1862 land-grant research institution, and will be performed in Minneapolis, MN. The research outcomes are expected to provide insights that can inform the development of therapeutic strategies specifically designed to target and impair the critical, but currently overlooked, aspect of cell-to-cell HIV transmission.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $231.0k | 7/25/25 |