Project Grant R21AI195420
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $270,591 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026 through March 31, 2028. The project deliverables focus on developing a multiplex binding antibody assay for confirmatory Herpes Simplex Virus types 1 and 2 (HSV-1/2) serological diagnosis. The funded research combines the advantages...
- Federal Project Grant Summary Fred Hutchinson Cancer Center received a $465,116 Project Grant award dated April 13, 2026, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research development and clinical translation of an innovative gene therapy approach for controlling genital herpes simplex virus (HSV) infection. The research team has demonstrated that adeno-associated virus...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Washington a Project Grant of $256,074 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 4, 2026, with a completion date of May 31, 2028. This grant supports the optimization and advanced pre-clinical development of an immunotherapeutic designed to boost CD8 T cell levels and localization in response to Herpes Simplex Virus (HSV) infection. The...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $3.55 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 12, 2025, with a completion date of August 31, 2029. The grant funds research assessing the effects of oral pre-exposure prophylaxis (PrEP) on the pharmacokinetics of monoclonal antibodies and vaccine-induced antibodies among...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $231,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period June 1, 2026 through May 31, 2028. This research initiative focuses on the identification, characterization, and development of human monoclonal antibodies (MAbs) for the treatment and prevention of Herpes Simplex Virus (HSV)...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Fred Hutchinson Cancer Center a Project Grant of $448,573 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This award supports the development of statistical methods and analytical tools to leverage immunologic biomarkers and complex molecular testing data for respiratory diseases vaccine development. The project...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $862,398 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2030. The award supports the development of novel Chimeric Antigen Receptor (CAR) T cell therapeutics designed to selectively target and deplete the HIV latent reservoir, specifically programmed cell death protein 1...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $220,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 9, 2026, with completion by January 31, 2028. The grant supports the development of novel statistical methods and two-phase sampling designs for assessing immune correlates of protection (COP)—biomarkers that predict vaccine-induced...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received $867,869 in project grant funding from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of June 3, 2026, and a completion date of May 31, 2031. The award supports research to identify and validate small molecule metabolites in vaginal fluid as diagnostic biomarkers for bacterial vaginosis (BV), vulvovaginal...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $190,944 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 8, 2025, with completion targeted for July 31, 2027. The grant supports systematic investigation of B cell dynamics and immune memory formation in human vaccination, specifically examining how different immunostimulatory adjuvants influence B...
Federal Project Grant Summary Fred Hutchinson Cancer Center (Seattle, WA) received a $238,899 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 8, 2026, with a completion date of May 31, 2028. The project, titled "Harnessing In-Tissue Antibodies for Therapeutic HSV Control," delivers comprehensive preclinical evaluation services of human monoclonal antibodies isolated from skin-based antibody-secreting cells (ASCs) to establish therapeutic efficacy for Herpes Simplex Virus Type 2 (HSV-2) prevention and treatment. The research products include in vitro and in vivo efficacy assessments conducted in mouse and guinea pig infection and reactivation models, leveraging advanced antibody engineering techniques to evaluate monoclonal antibodies with extended half-lives suitable for long-acting clinical use. This award addresses a significant public health need, as HSV-1/2 infections affect more than 4 billion people globally and current antiviral therapies fail to eliminate subclinical shedding or prevent neonatal herpes. The project builds on the institution's discovery of tissue-derived ASCs that secrete highly potent anti-HSV antibodies with superior potency and epitope diversity compared to previously tested human monoclonal antibodies. Deliverables include scientific data establishing the link between in vitro antibody activity and in vivo efficacy to support potential clinical development of tissue-derived monoclonal antibodies as novel therapeutics for HSV-2 prevention and functional cure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $238.9k | 6/9/26 |