This Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) is focused on evaluating the efficacy of the natural compound apigenin as a potential therapeutic countermeasure against gastrointestinal acute radiation syndrome (GI-ARS) in mice. The $158,500 award, effective July 22, 2025 through June 30, 2027, will support research to determine the most effective route of apigenin administration for counteracting radiation-induced intestinal damage and improving 30-day survival rates in irradiated mice. The primary recipient, The Research Foundation for the State University of New York (Stony Brook University), will conduct a series of tests on blood and tissue samples to assess hematological parameters, citrulline plasma levels, and histopathological effects following apigenin treatment after radiation exposure. This research aims to address the critical gap of approved countermeasures for GI-ARS, a condition that can arise from high-dose radiation exposure.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $158.5k | 7/22/25 |