Project Grant R21AI193738
- This Project Grant award of $781,129 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year study to validate and extend an integrated host-microbe (IHM) diagnostic approach for accurately diagnosing lower respiratory tract infections (LRTIs) in critically ill children. The study aims to: 1) validate the performance of the existing IHM LRTI diagnostic classifier, 2) develop a novel host gene expression...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,182,827 Project Grant to Duke University to develop a 3D bioprinted alveolar sac model and dual host-microbe spatial transcriptomics technology. The goal is to enhance understanding of how the lung microbiome regulates the host response to influenza virus infection. This Allergy and Infectious Diseases Research (CFDA 93.855) program grant will fund the creation of innovative in vitro technologies to study interactions...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $490,093 Project Grant to the University of Maryland, College Park on April 10, 2025. The funding supports the development of a rapid, inexpensive microfluidic technology to isolate bacteria directly from whole blood, identify pathogens, and evaluate their antibiotic response within 75 minutes. This will enable clinicians to move...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded Baebies, Inc., a $1,600,723 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a rapid, point-of-care diagnostic test to identify viable sexually transmitted infections (STIs). The project aims to create a panel of novel STI viability PCR (V-PCR) assays that can differentiate active infection from resolved, non-viable infections. This solution will utilize digital microfluidic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $999,316 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Pearl Diagnostics, Inc., a Baltimore-based small business. The grant supports the final integration and clinical testing required for FDA clearance of Pearl Diagnostics' lateral flow device (LFD) - a rapid, point-of-care urine test to diagnose invasive aspergillosis, an infection recently named a "critical" public...
- The federal Project Grant award of $3,089,360 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development and evaluation of innovative tuberculosis (TB) diagnostic platforms and assays. The 5-year project, awarded to Rutgers, The State University of New Jersey, aims to accelerate promising TB diagnostics through a fast-paced pipeline that includes technology scouting, development...
- This $160,546 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research towards developing a novel spatiotemporal machine learning framework for epidemic models of respiratory infections. The award to Emory University in Atlanta, Georgia, with a period of performance from September 3, 2025 through August 31, 2029, aims to advance foundational epidemiological...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $238,500 project grant to the University of California, San Diego (UC San Diego) to develop a novel electrochemical lateral flow assay (ELFA) for the point-of-need diagnosis of tuberculosis (TB). The objective is to create a highly sensitive and specific blood or urine test that can accurately distinguish active TB disease from...
- This $420,553 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a single-cell technique that will measure the translation rate and transcriptome of thousands of individual bacterial cells, with a focus on understanding antibiotic tolerance in Staphylococcus aureus during chronic infections. The research will explore the heterogeneity in...
- This $424,265 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on August 7, 2025 supports the development of an integrated "DIMS-RAMAN" platform to rapidly isolate and analyze bacterial cells from blood samples within 1-2 hours. The proposed system combines a novel density-shift immunocapture separation (DIMS) technique to directly separate microbial cells from whole blood, with Raman...
The federal Project Grant award of $244,044.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop an integrated diagnostic test that uses a single nasal swab sample to detect both pathogens and the host immune response in order to identify the cause of lower respiratory tract infections (LRTI). The award will enable the grantee, Duke University, to achieve the following specific aims over the project period from August 2025 to July 2027: 1) Develop a novel gene expression classifier to distinguish viral from non-viral LRTI using nasal swab samples, and 2) Design and validate an integrated pathogen and host gene expression test utilizing quantitative real-time PCR to identify viral versus non-viral LRTI etiology. This research seeks to address the global challenge of unclear LRTI etiology, which leads to antibiotic overuse and resistance, particularly in low- and middle-income countries with limited diagnostic capacity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $244.0k | 8/5/25 |