Project Grant R21AI193591
- Federal Grant Award Summary Saint Louis University received a $192,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with a completion date of January 31, 2028. The grant supports investigator-initiated biomedical research examining the molecular mechanisms underlying monocyte chemoattractant protein-1 (MCP-1) polymorphism-mediated susceptibility to...
- Federal Project Grant Summary Saint Louis University received a $259,125 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of April 1, 2026, and a completion date of March 31, 2028. The grant supports research to dissect the contribution of neutrophils to diabetes/tuberculosis (DM/TB) comorbidity, addressing a significant public health challenge where tuberculosis...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $426,938 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 23, 2025, with a completion date of May 31, 2027. The award supports the development of a simplified, cost-effective mouse model of chronic Mycobacterium abscessus lung disease using BALB/c mice that requires only weekly cyclophosphamide administration. This...
- Federal Project Grant Award Summary Saint Louis University received a Project Grant award of $416,625 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 11, 2025, with completion targeted for July 31, 2027. The award funds the PTSOMICS project, which focuses on machine learning-driven discovery and analysis of polymorphic toxin and effector systems (PTSS). The project deliverables...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $104,262 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 30, 2025, with a completion date of May 31, 2028. This research project, "Linking Mycobacterium tuberculosis Infection Outcomes with Transcriptional Networks in Genetically Diverse Mouse Macrophages," will advance...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant totaling $429,000.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of Colorado at Denver for the development and comprehensive characterization of the MAIT-Boost Knock-In (MBKI) mouse model. The award, issued February 1, 2026, with an ultimate completion date of January 31, 2028, supports research to create a novel...
- Federal Grant Award Summary Saint Louis University received a $627,222 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on May 18, 2026, with a completion date of April 30, 2031. This research project focuses on structure-guided functional analysis of hepadnaviral polymerase, specifically examining the viral reverse transcriptase enzyme responsible for hepatitis B virus (HBV)...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 9, 2026, with a completion date of January 31, 2028. The research project, "Eliciting TH1/TH17 Dual Responses for Vaccine-Induced Immunity to Tuberculosis," investigates mechanisms by which the Bacillus...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Health Research, Inc.'s Wadsworth Center a $1.38M Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop therapeutic products and conduct research on mycobacteriophage lysin (LYSB) as a treatment for Mycobacterium abscessus (MAB) infections. The project, initiated July 18, 2025, and extending through June 30, 2030, focuses on translating preclinical...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025, for a project period extending through June 30, 2027. The award supports research to identify novel immune determinants influencing Staphylococcus aureus biofilm infection using Collaborative Cross (CC) mouse lines. The research addresses gaps in...
Saint Louis University received a $423,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of June 2, 2026 through May 31, 2028. The award supports research utilizing SCNN1B transgenic mice to develop vaccines against pulmonary Mycobacterium avium complex (MAC), a leading cause of nontuberculous mycobacterial (NTM) infections in patients with underlying lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. The research delivers two primary products: (1) characterization of lung pathology, MAC growth, and immune response following aerosol MAC infection in SCNN1B-transgenic mice compared to standard laboratory mouse strains, with mucosal immunity measured through lung T-cell flow cytometry and bronchoalveolar lavage cytokine analysis; and (2) efficacy evaluation of DAR-901 and BCG vaccines for pulmonary MAC infection in the transgenic mouse model. These research outputs address the significant clinical challenge of MAC treatment failure rates ranging from 30-40% despite prolonged multi-drug therapy, providing preclinical evidence to inform future vaccine and therapeutic development for this resistant infection.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 6/3/26 |