Project Grant R21AI193316
- This $210,867 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a cell-based therapy for generating donor-specific immune tolerance in kidney transplant recipients. The project will engineer "push/pull" particle-loaded tolerogenic dendritic cells (PPP-TolDCs) that can be infused into donor kidneys prior to transplantation. These engineered PPP-TolDCs...
- This federal Project Grant award of $644,770 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), will support research to determine the impact of immunosuppression on the risk of post-transplant lymphoproliferative disorder (PTLD) and Epstein-Barr virus (EBV) infection in kidney transplant recipients receiving EBV-seropositive donor organs. The project aims to identify modifiable risk factors,...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at New York University (NYU) to develop personalized immunosuppression regimens for kidney transplant recipients. The $847,371 award, with a project period from September 15, 2025 to July 31, 2030, will leverage a large nationwide electronic health record database to...
- This federal Project Grant award, in the amount of $766,265, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to understand the role of regulatory T cells (Tregs) in promoting donor-specific transplantation tolerance, which could improve outcomes for transplant patients by eliminating the need for chronic immunosuppression. Key areas of investigation include...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $153,512 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University. The grant will fund research to characterize the renal immune microenvironment in antibody-mediated rejection (ABMR) of kidney transplants in order to develop improved diagnostics and predict treatment response. The research will utilize advanced imaging mass cytometry to profile...
- This $612,975 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to develop an approach combining T cell costimulation blockade and inhibition of monocyte allorecognition via CD47 to achieve long-term acceptance of solid organ transplants without the need for ongoing immunosuppression. The research aims...
- The University of Pittsburgh received a $1,455,073 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The 5-year grant, commencing on July 3, 2025, aims to develop innovative approaches to enhance regulatory immune cell function and improve kidney allograft survival in non-human primates. Key research activities include: Evaluating whether a novel myeloid cell...
- This $235,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development of infrastructure and documents to conduct a clinical trial evaluating the use of intravenous immunoglobulin (IVIG) to treat BK polyomavirus infections in pediatric kidney transplant recipients. The award will fund a planning grant to establish a prospective cohort of 120 pediatric kidney transplant recipients...
- This Project Grant award of $402,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to evaluate the use of anti-CD154 monoclonal antibody therapy in a nonhuman primate vascularized composite allograft (VCA) model. The research aims to determine the efficacy of this approach in regulating the host immune response and promoting transplantation tolerance, particularly in sensitized...
- The federal Project Grant award of $3,106,301 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate the mechanisms underlying induction and maintenance of immunosuppression and the impact on T cell function after kidney transplantation. The project aims to analyze epigenetic, transcriptional, and immune phenotype changes associated with the use of antithymocyte globulin (ATG)...
This Project Grant award of $441,522 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program supports research to reduce the need for systemic immunosuppression in kidney transplant patients. The objective is to test the efficacy and safety of pre-transplant modification of the kidney graft with a small molecule integrin inhibitor, delivered via ex vivo perfusion, to decrease immune cell recruitment and improve transplant outcomes without impairing systemic immunity. The research will be conducted by Baylor University and focus on a well-characterized murine kidney transplant model. If successful, this novel graft modification strategy could lead to improved transplant success and reduced immunosuppression requirements for transplant recipients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.5k | 8/25/25 |