This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research - totals $718,758 over the period of September 1, 2024 to August 31, 2025. The grant aims to explore the use of an IL-21-IgFc fusion protein as a host-directed immunotherapy to enhance immunity in individuals with tuberculosis (TB)/HIV co-infection. Specifically, the research will investigate whether supplementing...
This $1,011,348 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the first interactions of Mycobacterium tuberculosis (M.TB) with the human alveolar environment, particularly alveolar lining fluid (ALF) and alveolar cells, are impacted by HIV infection. The research aims to determine how M.TB exposure to ALF from people living with HIV leads to...
This $1,297,775 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to investigate the role of sirtuins in regulating interactions between tuberculosis (TB) and HIV infections in macrophages. The primary awardee, The Methodist Hospital Research Institute, aims to:
Analyze the impact of early TB and HIV infection on sirtuin gene and protein induction in macrophages, and develop an...
The Washington University has been awarded a $772,420 federal Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) from the National Institute of Allergy and Infectious Diseases, a component of the National Institutes of Health. The grant will fund a 5-year research project to investigate the role of SLAMF1 (a cell surface molecule) in regulating macrophage-T cell interactions and immunity against tuberculosis (TB). The project aims to determine how SLAMF1...
This $104,552 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Washington University in St. Louis to conduct research on how the tuberculosis-causing bacterium Mycobacterium tuberculosis (MTB) promotes its survival within neutrophils, the most abundant immune cells infected during active tuberculosis.
The key objectives of this 1.5-year research project are to: 1) investigate how the MTB's...
The federal Project Grant award R01AI177653, totaling $447,009.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research at the University of Massachusetts (UMass) to evaluate mechanisms that regulate alveolar macrophage (AM) responses to Mycobacterium tuberculosis (MTB) infection, with the goal of better understanding early events during tuberculosis (TB)...
This federal Project Grant award of $1,738,361.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to modulate indoleamines and optimize immunity in the setting of Mycobacterium tuberculosis (MTB)/HIV co-infection. The award, with a period of performance from June 2024 to April 2029, will be used by the Texas Biomedical Research Institute to conduct detailed longitudinal and...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), is supporting a $2,817,044 research program on "Systems Genetics of Tuberculosis" over 5 years. The project aims to use a mouse model system and human clinical samples to identify biological pathways influencing tuberculosis infection outcomes. Key activities include:
Leveraging genetic diversity in mouse and bacterial...
This federal Project Grant award of $473,262 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the role of the NR4A1 nuclear receptor in regulating the function of CD8+ T cells in tuberculosis (TB). The primary awardee, the University of Massachusetts Medical School, will conduct experiments to confirm prior findings that NR4A1 deficiency enhances the ability of CD8+ T...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support a comprehensive study to characterize the immune response to tuberculosis (TB) across different disease states. The $517,185 award to the University of California, Davis, with a sub-award to Stellenbosch University in South Africa, will fund the integration of single-cell multi-omics profiling and ancestry-adjusted expression...