This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $155,204 to the University of Notre Dame to conduct research aimed at improving the predictive modeling of T cell receptor (TCR) cross-reactivity. The project seeks to develop an extended positional scanning library (EPSL) approach to generate diverse peptide datasets, which will be leveraged with advanced structural modeling and machine...
This $606,609 Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, San Diego (UCSD) to develop T cell alloreactivity and organ transplant risk stratification models using high-resolution HLA and genomic data. The research aims to advance understanding of immune system responses and improve clinical outcomes for organ transplant recipients. The 5-year...
This Project Grant award for $327,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better understand the role of the CD43 receptor on effector CD8+ T cells during acute allograft rejection. The key objectives are to: Define the effector mechanisms that distinguish CD43+ effector T cells from CD43- effector T cells, including their differentiation pathways, trafficking...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $612,975.00 to the University of Pittsburgh to conduct research on "Targeting Monocyte Allorecognition to Achieve Allograft Acceptance". The goal is to develop a model for inducing long-term organ transplant acceptance by combining T-cell costimulation blockade with inhibition of monocyte allorecognition via CD47. The research...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $231,131 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Duquesne University of the Holy Spirit to develop injectable 3D-clustered human fibroblastic reticular cells (clFRCs) for expanding regulatory T cells (Tregs) to manage allograft transplant rejection. The 2-year project, running from June 2025 to May 2027, aims to optimize the clFRC prototype to generate Tregs in vitro and characterize the...
The University of Pittsburgh received a $679,937 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on mechanisms and therapeutic targeting of T cell regulation in heart allograft recipient monkeys. The 5-year project aims to investigate the impact of cytokine modulation and administration of novel, donor-specific chimeric antigen receptor regulatory T cells (CARTREG) on promoting long-term...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,194,992 to the University of California, San Diego (UC San Diego) to conduct research on the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The key objectives are to: (1) evaluate the role of tissue-resident CD8 T cells in intestinal hyper-permeability and colitis during a sustained viral...
This federal Project Grant award of $1,310,631.89, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports the development and optimization of antibody-targeted nanoparticle delivery systems to selectively target endothelial cells in human organ allografts. The goal is to prevent the expression of surface proteins that contribute to T cell-mediated rejection and improve long-term graft outcomes, thereby reducing the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,135,986 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to investigate strategies for mitigating cytomegalovirus (CMV) reactivation in kidney transplant recipients. The research aims to identify cellular and molecular targets, specifically related to endoplasmic reticulum stress and mitochondrial dysfunction in renal endothelial cells, that can be...
This Project Grant award of $459,439 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research at the University of Notre Dame DU Lac focused on improving understanding of alloantigen recognition by CD8+ T cells in acute cellular rejection (ACR) of transplanted tissues. The research aims to 1) define the alloantigens recognized by viral-specific T cell receptors (TCRs) in a mouse model, and 2) apply this knowledge to identifying alloantigens recognized by human cells. This work builds on the investigators' preliminary findings demonstrating that viral reactivity can serve as a "hook" for identifying molecular mimics that drive alloreactivity and ACR. The award period is from July 7, 2025 to June 30, 2027.